Therapeutic Action
Antidote to folate antagonists
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Drug reference
Antidote to folate antagonists
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Prevention of haemotological toxicity of pyrimethamine when pyrimethamine is used as prophylaxis for, or in the treatment of toxoplasmosis or isosporiasis in immunodeficient patients
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Pregnancy: NO CONTRA-INDICATION Breast-feeding: NO CONTRA-INDICATION
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15 mg tablet Also comes in 5 mg and 25 mg capsules.
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When pyrimethamine is used as primary or secondary prophylaxis for toxoplasmosis Adult: 25 to 30 mg once weekly During treatment of toxoplasmosis Adult: 10 to 25 mg once daily During treatment of isosporiasis Adult: 5 to 15 mg once daily
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For the duration of the pyrimethamine treatment
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Folic acid cannot be used as an alternative to folinic acid for the treatment of toxoplasmosis: folic acid reduces the antiprotozoal activity of pyrimethamine. Calcium folinate is also called calcium leucovorin.
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- below 25 °C
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25 to 30 mg once weekly
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10 to 25 mg once daily
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5 to 15 mg once daily
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