Drug reference

Carglumic acid

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1152

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Hyperammonaemia due to N-acetylglutamate synthase deficiency (under expert supervision) ▶BY MOUTH ▶Adult: Initially 50–125 mg/kg twice daily, to be taken immediately before food, dose adjusted according to plasma–ammonia concentration; maintenance 5–50 mg/kg twice daily, the total daily dose may alternatively be given in 3–4 divided doses Hyperammonaemia due to organic acidaemia (under expert supervision) ▶BY MOUTH ▶Adult: Initially 50–125 mg/kg twice daily, to be taken immediately before food, dose adjusted according to plasma-ammonia concentration, the total daily dose may alternatively be given in 3–4 divided doses

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Safety

Important Safety Information

EMERGENCY MANAGEMENT OF UREA CYCLE DISORDERS For further information on the emergency management of urea cycle disorders consult the British Inherited Metabolic Disease Group (BIMDG) website at www.bimdg.org.uk.

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Side Effects

▶Common or very common Hyperhidrosis ▶Uncommon Bradycardia. diarrhoea. fever. vomiting ▶Frequency not known Rash

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Pregnancy

Manufacturer advises avoid unless essential—no information available.

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Breast Feeding

Manufacturer advises avoid—present in milk in animal studies.

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Dose and formulations

Directions For Administration

Dispersible tablets must be dispersed in at least 5–10 mL of water and taken orally immediately, or administered via a nasogastric tube.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Dispersible tablet CAUTIONARY AND ADVISORY LABELS 13 ▶Carglumic acid (Non-proprietary) Carglumic acid 200 mg Carglumic acid 200mg dispersible tablets sugar-free | 5 tablet P £218.69 sugar-free | 15 tablet P £625.37 sugar-free | 60 tablet P £2,624.30 ▶Carbaglu (Recordati Rare Diseases UK Ltd) Carglumic acid 200 mg Carbaglu 200mg dispersible tablets sugar- free | 5 tablet P £299.00 sugar-free | 15 tablet P £897.00 sugar-free | 60 tablet P £3,499.00 ▶Ucedane (Eurocept International bv) Carglumic acid 200 mg Ucedane 200mg dispersible tablets sugar- free | 12 tablet P £660.00 sugar-free | 60 tablet P £3,300.00 DRUGS FOR METABOLIC DISORDERS › AMMONIA LOWERING DRUGS

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Dose text by age group

Adult

Initially 50–125 mg/kg twice daily, to be taken

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1152

Adult

Initially 50–125 mg/kg twice daily, to be taken

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1152

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Carglumic acid

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1152

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1152

Safety

Important Safety Information

PDF page 1152

Side Effects

▶Common or very common Hyperhidrosis ▶Uncommon Bradycardia. diarrhoea. fever. vomiting ▶Frequency not known Rash

PDF page 1152

Pregnancy

Manufacturer advises avoid unless essential—no information available.

PDF page 1152

Breast Feeding

Manufacturer advises avoid—present in milk in animal studies.

PDF page 1152

Dose and formulations

Directions For Administration

Dispersible tablets must be dispersed in at least 5–10 mL of water and taken orally immediately, or administered via a nasogastric tube.

PDF page 1152

Medicinal Forms

PDF page 1152

Dose text by age group

Adult

Initially 50–125 mg/kg twice daily, to be taken

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1152

Adult

Initially 50–125 mg/kg twice daily, to be taken

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1152

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.