Indications And Dose
Schizophrenia ▶BY MOUTH ▶Adult: 1.5 mg once daily, increased in steps of 1.5 mg if required; maximum 6 mg per day
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Drug reference
Schizophrenia ▶BY MOUTH ▶Adult: 1.5 mg once daily, increased in steps of 1.5 mg if required; maximum 6 mg per day
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Scottish Medicines Consortium (SMC) decisions SMC No. SMC2137 The Scottish Medicines Consortium has advised (May 2019) that cariprazine (Reagila ®) is accepted for use within NHS Scotland as second-line treatment for schizophrenia in adults where predominantly negative symptoms have been identified as an important feature.
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→Appendix 1: cariprazine
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▶Common or very common Anxiety. appetite abnormal. bradyphrenia. drooling. dyslipidaemia. eye disorders. fatigue. gait abnormal. hypertension. joint stiffness. muscle complaints. musculoskeletal stiffness. nausea. oral disorders. pain. reflexes abnormal. sleep disorders. speech impairment. teeth grinding. vision disorders ▶Uncommon Anaemia. cardiac conduction disorder. delirium. depression. diabetes mellitus. dysaesthesia. eosinophilia. eye irritation. gastrooesophageal reflux disease. grimacing. hiccups. pruritus. sexual dysfunction . suicidal behaviour. thirst. urinary disorders. vertigo ▶Rare or very rare Cataract. dysphagia. hypothyroidism. memory loss. rhabdomyolysis ▶Frequency not known Hepatitis toxic
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Manufacturer advises highly effective contraception in women of childbearing potential during treatment and for at least 10 weeks after the last dose; addition of barrier method recommended in women using systemically-acting hormonal contraceptives.
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Manufacturer advises avoid—toxicity in animal studies.
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Manufacturer advises avoid—present in milk in animal studies.
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Manufacturer advises avoid in severe impairment (no information available).
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Manufacturer advises avoid in severe impairment (no information available).
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There can be variation in the licensing of different medicines containing the same drug. Capsule ▶Reagila (Recordati Pharmaceuticals Ltd) A Cariprazine (as Cariprazine hydrochloride) 1.5 mg Reagila 1.5mg capsules | 28 capsule P £80.36 DT = £80.36 Cariprazine (as Cariprazine hydrochloride) 3 mg Reagila 3mg capsules | 28 capsule P £80.36 DT = £80.36 Cariprazine (as Cariprazine hydrochloride) 4.5 mg Reagila 4.5mg capsules | 28 capsule P £80.36 DT = £80.36 Cariprazine (as Cariprazine hydrochloride) 6 mg Reagila 6mg capsules | 28 capsule P £80.36 DT = £80.36 eiiii F 401
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1.5 mg once daily, increased in steps of 1.5 mg if
First-line fragment. Read the complete Indications and Dose section above.
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