Indications And Dose
Susceptible infections due to sensitive Gram-positive and Gram-negative bacteria ▶BY MOUTH ▶Child 1–11 months: 12.5 mg/kg twice daily, alternatively 125 mg twice daily ▶Child 1–4 years: 12.5 mg/kg twice daily, alternatively 125 mg 3 times a day ▶Child 5–11 years: 12.5 mg/kg twice daily, alternatively 250 mg 3 times a day ▶Child 12–17 years: 500 mg 2–3 times a day ▶Adult: 250 mg every 6 hours, alternatively 500 mg every 8–12 hours; increased to 1–1.5 g every 6–8 hours, increased dose to be used for severe infections Serious susceptible infections due to sensitive Gram- positive and Gram-negative bacteria ▶BY MOUTH ▶Child 1 month–11 years: 25 mg/kg 2–4 times a day (max. per dose 1 g 4 times a day) ▶Child 12–17 years: 1–1.5 g 3–4 times a day Hospital-acquired pneumonia | Acute diverticulitis [in combination with metronidazole] Infection ▶BY MOUTH ▶Adult: 500 mg 2–3 times a day; increased if necessary to 1–1.5 g 3–4 times a day for 5 days then review, use increased dose in severe infection Prophylaxis of recurrent urinary-tract infection ▶BY MOUTH ▶Child 3 months–15 years: 12.5 mg/kg once daily (max. per dose 125 mg), dose to be taken at night ▶Child 16–17 years: 125 mg once daily, dose to be taken at night, alternatively 500 mg for 1 dose, following exposure to a trigger ▶Adult: 125 mg once daily, dose to be taken at night, alternatively 500 mg for 1 dose, following exposure to a trigger Acute pyelonephritis | Urinary-tract infection (catheter- associated) ▶BY MOUTH ▶Child 3–11 months: 12.5 mg/kg twice daily for 7 to 10 days, alternatively 125 mg twice daily; increased if necessary to 25 mg/kg 2–4 times a day (max. per dose 1 g 4 times a day), increased dose used in severe infections ▶Child 1–4 years: 12.5 mg/kg twice daily, alternatively 125 mg 3 times a day for 7 to 10 days; increased if necessary to 25 mg/kg 2–4 times a day (max. per dose 1 g 4 times a day), increased dose used in severe infections ▶Child 5–11 years: 12.5 mg/kg twice daily, alternatively 250 mg 3 times a day for 7 to 10 days; increased if necessary to 25 mg/kg 2–4 times a day (max. per dose 1 g 4 times a day), increased dose used in severe infections ▶Child 12–17 years: 500 mg 2–3 times a day for 7 to 10 days; increased to 1–1.5 g 3–4 times a day, increased dose used in severe infections ▶Adult: 500 mg 2–3 times a day for 7 to 10 days; increased if necessary to 1–1.5 g 3–4 times a day, increased dose used in severe infections Lower urinary-tract infection in pregnancy ▶BY MOUTH ▶Child 12–17 years: 500 mg twice daily for 7 days ▶Adult: 500 mg twice daily for 7 days Lower urinary-tract infection ▶BY MOUTH ▶Child 3–11 months: 12.5 mg/kg twice daily, alternatively 125 mg twice daily for 3 days ▶Child 1–4 years: 12.5 mg/kg twice daily, alternatively 125 mg 3 times a day for 3 days ▶Child 5–11 years: 12.5 mg/kg twice daily, alternatively 250 mg 3 times a day for 3 days ▶Child 12–15 years: 500 mg twice daily for 3 days l UNLICENSED USE g Cefalexin is used for prophylaxis of recurrent urinary-tract infection, h but is not licensed for this indication.
PDF page 573