Indications And Dose
Hospital-acquired pneumonia (excluding ventilator- associated pneumonia) | Community-acquired pneumonia ▶BY INTRAVENOUS INFUSION ▶Adult: 500 mg every 8 hours
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Drug reference
Hospital-acquired pneumonia (excluding ventilator- associated pneumonia) | Community-acquired pneumonia ▶BY INTRAVENOUS INFUSION ▶Adult: 500 mg every 8 hours
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Pre-existing seizure disorder—increased risk of seizures. supra-normal creatinine clearance CAUTIONS, FURTHER INFORMATION ▶Supra-normal creatinine clearance Manufacturer advises to measure baseline renal function and increase duration of infusion if creatinine clearance greater than 150 mL/minute.
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→Appendix 1: cephalosporins
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▶Common or very common Drowsiness. dyspepsia. electrolyte imbalance. fungal infection. hypersensitivity. taste altered ▶Uncommon Anaemia. antibiotic associated colitis. anxiety . asthma. dyspnoea. laryngeal pain. muscle spasms. peripheral oedema. renal failure. sleep disorders. thrombocytosis ▶Frequency not known Seizure
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Manufacturer advises avoid unless essential—no information available.
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Manufacturer advises avoid—present in milk in animal studies.
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Manufacturer advises use with caution in severe impairment—limited information available. Dose adjustments Reduce dose to 500 mg every 12 hours in moderate impairment and 250 mg every 12 hours in severe impairment.
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Manufacturer advises for intravenous infusion (Zevtera ®), give intermittently in Glucose 5%, or Sodium Chloride 0.9%, or Lactated Ringer’s solution; reconstitute each 500 mg with 10 mL Water for injections or Glucose 5%; dilute in 250 mL infusion fluid and give over 2 hours (increased to 4 hours if creatinine clearance greater than 150 mL/minute). Do not mix with calcium-containing solutions (except Lactated Ringer’s solution) in the same intravenous line—precipitation may occur. l HANDLING AND STORAGE Manufacturer advises store in a refrigerator (2–8°C)—consult product literature for storage after reconstitution and dilution.
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There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion ELECTROLYTES: May contain Sodium ▶Zevtera (Correvio UK Ltd) Ceftobiprole (as Ceftobiprole medocaril sodium) 500 mg Zevtera 500mg powder for concentrate for solution for infusion vials | 10 vial P £396.30 (Hospital only) ANTIBACTERIALS › GLYCOPEPTIDE ANTIBACTERIALS
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Driving and skilled tasks Manufacturer advises patients and carers should be counselled on the effects on driving and performance of skilled tasks—increased risk of dizziness.
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500 mg every 8 hours
First-line fragment. Read the complete Indications and Dose section above.
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