Drug reference

Celecoxib

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1217, 1218

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Pain and inflammation in osteoarthritis Musculoskeletal system ▶BY MOUTH ▶Adult: 200 mg daily in 1–2 divided doses, then increased if necessary up to 200 mg twice daily, discontinue if no improvement after 2 weeks on maximum dose Pain and inflammation in rheumatoid arthritis ▶BY MOUTH ▶Adult: 100 mg twice daily, then increased if necessary to 200 mg twice daily, discontinue if no improvement after 2 weeks on maximum dose Ankylosing spondylitis ▶BY MOUTH ▶Adult: 200 mg daily in 1–2 divided doses, then increased if necessary up to 400 mg daily in 1–2 divided doses, discontinue if no improvement after 2 weeks on maximum dose

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Dose Adjustments

DUE TO INTERACTIONS ▶Manufacturer advises reduce dose by half with concurrent use of ﬂuconazole.

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Contra Indications

Active gastro-intestinal bleeding. active gastro-intestinal ulceration. cerebrovascular disease. inﬂammatory bowel disease. ischaemic heart disease. mild to severe heart failure. peripheral arterial disease

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Cautions

Allergic disorders. cardiac impairment (NSAIDs may impair renal function). coagulation defects. connective-tissue disorders. dehydration (risk of renal impairment). elderly (risk of serious side-effects and fatalities). history of cardiac failure. history of gastro- intestinal disorders. hypertension. left ventricular dysfunction. oedema. risk factors for cardiovascular events

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Allergy And Cross Sensitivity

Contra-indicated in patients with a history of hypersensitivity to aspirin or any other NSAID—which includes those in whom attacks of asthma, angioedema, urticaria or rhinitis have been Musculoskeletal system precipitated by aspirin or any other NSAID. Contra-indicated in patients with sulfonamide sensitivity.

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Safety

Interactions

→Appendix 1: NSAIDs

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Side Effects

▶Common or very common Angina pectoris. benign prostatic hyperplasia. cough. diarrhoea. dizziness. dysphagia. dyspnoea. ﬂuid retention. gastrointestinal discomfort. gastrointestinal disorders. headache. hypersensitivity. hypertension. increased risk of infection. inﬂuenza like illness. injury. insomnia. irritable bowel syndrome. joint disorders. muscle tone increased. myocardial infarction. nausea. nephrolithiasis. oedema. skin reactions. vomiting. weight increased ▶Uncommon Anaemia. anxiety. arrhythmias. breast tenderness. burping. cerebral infarction. chest pain. conjunctivitis. constipation. depression. drowsiness. dysphonia. electrolyte imbalance. embolism and thrombosis. fatigue. haemorrhage. hearing impairment. heart failure. hepatic disorders. lipoma. lower limb fracture. muscle complaints. nocturia. oral disorders. palpitations. paraesthesia. respiratory disorders. tinnitus . vision blurred. vitreous ﬂoater ▶Rare or very rare Acute kidney injury (more common in patients with pre-existing renal impairment). alopecia. angioedema. anosmia. ataxia. confusion. ﬂushing. hallucination. intracranial haemorrhage. leucopenia. meningitis aseptic. menstrual disorder. myositis. nephritis tubulointerstitial. nephropathy. pancreatitis. pancytopenia. photosensitivity reaction. seizures. severe cutaneous adverse reactions (SCARs). taste altered. thrombocytopenia. vasculitis ▶Frequency not known Infertility SIDE-EFFECTS, FURTHER INFORMATION For information about cardiovascular and gastrointestinal side-effects, and a possible exacerbation of symptoms in asthma, see Non- steroidal anti-inﬂammatory drugs. p. 1193

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Conception And Contraception

Caution—long-term use of some NSAIDs is associated with reduced female fertility, which is reversible on stopping treatment.

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Pregnancy

Avoid (teratogenic in animal studies).

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Breast Feeding

Avoid—present in milk in animal studies.

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Hepatic Impairment

Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment (no information available). Dose adjustments Manufacturer advises initial dose reduction of 50% in moderate impairment.

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Renal Impairment

Avoid if possible or use with caution. Avoid if eGFR less than 30 mL/minute/1.73 m2. Dose adjustments The lowest effective dose should be used for the shortest possible duration. Monitoring In renal impairment monitor renal function; sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure.

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Monitoring Requirements

Monitor blood pressure before and during treatment.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Capsule ▶Celecoxib (Non-proprietary) Celecoxib 100 mg Celecoxib 100mg capsules | 60 capsule P £21.55 DT = £2.30 Celecoxib 200 mg Celecoxib 200mg capsules | 30 capsule P £21.55 DT = £3.99 ▶Celebrex (Upjohn UK Ltd) Celecoxib 100 mg Celebrex 100mg capsules | 60 capsule P £21.55 DT = £2.30 Celecoxib 200 mg Celebrex 200mg capsules | 30 capsule P £21.55 DT = £3.99

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Dose text by age group

Adult

200 mg daily in 1–2 divided doses, then

First-line fragment. Read the complete Indications and Dose section above.

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Adult

100 mg twice daily, then increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1217

Adult

200 mg daily in 1–2 divided doses, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1217

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Celecoxib

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1217, 1218

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1217

Dose Adjustments

DUE TO INTERACTIONS ▶Manufacturer advises reduce dose by half with concurrent use of ﬂuconazole.

PDF page 1217

Contra Indications

PDF page 1217

Cautions

PDF page 1217

Allergy And Cross Sensitivity

PDF page 1218

Safety

Interactions

→Appendix 1: NSAIDs

PDF page 1217

Side Effects

PDF pages 1217, 1218

Conception And Contraception

Caution—long-term use of some NSAIDs is associated with reduced female fertility, which is reversible on stopping treatment.

PDF page 1218

Pregnancy

Avoid (teratogenic in animal studies).

PDF page 1218

Breast Feeding

Avoid—present in milk in animal studies.

PDF page 1218

Hepatic Impairment

PDF page 1218

Renal Impairment

PDF page 1218

Monitoring Requirements

Monitor blood pressure before and during treatment.

PDF page 1218

Dose and formulations

Medicinal Forms

PDF page 1218

Dose text by age group

Adult

200 mg daily in 1–2 divided doses, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1217

Adult

100 mg twice daily, then increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1217

Adult

200 mg daily in 1–2 divided doses, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1217

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.