Names and pronunciation
(cerr-ah-tin′ib) Zykadia
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Drug reference
(cerr-ah-tin′ib) Zykadia
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Func. class.: Antineoplastic— miscellaneous
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USES: Anaplastic lymphoma kinase (ALK)–positive metastatic non– small-cell lung cancer (NSCLC) in patients who have progressed on or are intolerant to crizotinib
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CONTRAINDICATIONS: Preg- nancy, hypersensitivity, QT prolongation Precautions: Breastfeeding, children, geriatric patients, cardiac/hepatic dis- ease, GI bleeding, bone marrow suppres- sion, infection, diarrhea, hyperglycemia, diabetes mellitus, nausea/vomiting, pancreatitis, pneumonitis, QT prolonga- tion, torsades de pointes, bradycardia, cardiac arrhythmias, electrolyte imbal- ances, corticosteroid therapy C
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DOSAGE AND ROUTES • Adult: PO 450 mg daily on an empty stomach until disease progression or un- acceptable toxicity. Decrease dose by 1⁄3, round to nearest 150 mg with strong 3A4 inhibitors or inducers
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Available forms: Capsules 150 mg See cephalosporins—first generation HIGH ALERT
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• Adult: PO 450 mg daily on an empty stomach until disease progression or un- acceptable toxicity. Decrease dose by 1⁄3, round to nearest 150 mg with strong 3A4 inhibitors or inducers
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