Therapeutic Action
Phenicol antibacterial
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Drug reference
Phenicol antibacterial
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Plague meningitis
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Do not administer to children under 1 year. Do not administer to patients with: history of allergic reaction or bone marrow depression during a previous treatment with chloramphenicol; G6PD deficiency. May cause: dose-related haematological toxicity (bone marrow depression, anaemia, leucopenia, thrombocytopenia), allergic reactions. In these events, stop treatment immediately; gastrointestinal disturbances, peripheral and optic neuropathies. Reduce dosage in patients with hepatic or renal impairment. Avoid or monitor combination with potentially haematotoxic drugs (carbamazepine, co- trimoxazole, flucytocine, pyrimethamine, zidovudine, etc.). Pregnancy and breast-feeding: no contra-indication for plague meningitis. rd If used during the 3 trimester of pregancy, risk of grey syndrome in the neonate (vomiting, hypothermia, blue-grey skin colour and cardiovascular depression). If used during breast-feeding, monitor neonate for haematological disorders and gastrointestinal disturbances.
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1 g powder for injection, to be dissolved in 10 ml of water for injection, for IV injection over 1 to 2 minutes
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Child 1 to 12 years: 25 mg/kg every 8 hours for 10 to 14 days Child 13 years and over and adult: 1 g every 8 hours for 10 to 14 days 1 g vial Age Weight (to be dissolved in 10 ml) 1 to < 2 years 10 to < 13 kg 3 ml x 3 2 to < 3 years 13 to < 15 kg 3.5 ml x 3 3 to < 6 years 15 to < 20 kg 5 ml x 3 6 to < 8 years 20 to < 25 kg 6 ml x 3 8 to < 9 years 25 to < 30 kg 7 ml x 3 9 to < 11 years 30 to < 35 kg 8 ml x 3 11 to < 13 years 35 to < 45 kg 9 ml x 3 ≥ 13 years and adult ≥ 45 kg 10 ml x 3
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– Below 25 °C
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25 mg/kg every 8 hours for 10 to 14 days
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1 g every 8 hours for 10 to 14 days
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