Names and pronunciation
(klor-dye-az-e-pox′ide)
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Drug reference
(klor-dye-az-e-pox′ide)
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Func. class.: Antianxiety
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Chem. class.: Benzodiazepine, long-acting Controlled Substance Schedule IV
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USES: Short-term management of anxiety, acute alcohol withdrawal, preop- eratively for relaxation
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CONTRAINDICATIONS: Preg- nancy, breastfeeding, children <6 yr, hyper- sensitivity to benzodiazepines, closed- angle glaucoma, psychosis Precautions: Geriatric patients, debili- tated, renal/hepatic disease, suicidal ide- ation, abrupt discontinuation, respiratory depression, Parkinson’s disease, myasthe- nia gravis
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DOSAGE AND ROUTES Mild anxiety • Adult: PO 5-10 mg tid-qid • Geriatric: PO 5 mg bid initially, increase as needed • Child >6 yr: PO 5 mg bid-qid, max 10 mg bid-tid Severe anxiety • Adult: PO 20-25 mg 3-4 times per day, max 100 mg/day Preoperatively • Adult: PO 5-10 mg tid-qid on day be- fore surgery Alcohol withdrawal • Adult: PO 50-100 mg q4-6hr prn, max 300 mg/day Renal disease • Adult: PO CCr <10 mL/min, give 50% dose
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Available forms: Capsules 5, 10, 25 mg
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• Adult: PO 5-10 mg tid-qid
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• Adult: PO 20-25 mg 3-4 times per day, max 100 mg/day Preoperatively
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• Adult: PO 5-10 mg tid-qid on day be- fore surgery Alcohol withdrawal
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• Adult: PO 50-100 mg q4-6hr prn, max 300 mg/day Renal disease
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• Adult: PO CCr <10 mL/min, give 50% dose
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