Drug reference

Chlormethine

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 967

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Chlormethine is an alkylating agent which inhibits rapidly proliferating cells.

PDF page 967

Indications And Dose

Mycosis fungoides (initiated by a specialist) ▶TO THE SKIN ▶Adult: Apply once daily, apply thinly to the affected areas, for dose adjustments due to side-effects of the skin—consult product literature

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Cautions

Avoid contact with mucous membranes

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Safety

Interactions

→Appendix 1: chlormethine

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Side Effects

▶Common or very common Hypersensitivity. skin infection. skin reactions. skin ulcer

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Conception And Contraception

Manufacturer advises contraception in women of child-bearing potential during treatment. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.

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Pregnancy

Manufacturer advises avoid—toxicity in animal studies following systemic administration. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938

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Breast Feeding

Manufacturer advises avoid—no information available.

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Dose and formulations

Directions For Administration

Manufacturer advises apply to dry skin at least 4 hours before or 30 minutes after showering or washing. The treated area should be allowed to dry for 5 to 10 minutes. l HANDLING AND STORAGE Manufacturer advises store in a refrigerator (2–8 °C)—consult product literature for storage in a freezer.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Gel EXCIPIENTS: May contain Butylated hydroxytoluene, propylene glycol ▶Ledaga (Recordati Rare Diseases UK Ltd) Chlormethine hydrochloride 160 microgram per 1 gram Ledaga 160micrograms/g gel | 60 gram P £1,000.00

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Clinical care

Patient And Carer Advice

Patients and carers should be advised to wash hands after each application and should wear nitrile gloves for each application. If non-affected areas are exposed, these areas should be washed. Occlusive dressings should not be applied over the treated area.

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Dose text by age group

Adult

Apply once daily, apply thinly to the affected

First-line fragment. Read the complete Indications and Dose section above.

PDF page 967

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Chlormethine

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 967

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Chlormethine is an alkylating agent which inhibits rapidly proliferating cells.

PDF page 967

Indications And Dose

PDF page 967

Cautions

Avoid contact with mucous membranes

PDF page 967

Safety

Interactions

→Appendix 1: chlormethine

PDF page 967

Side Effects

▶Common or very common Hypersensitivity. skin infection. skin reactions. skin ulcer

PDF page 967

Conception And Contraception

Manufacturer advises contraception in women of child-bearing potential during treatment. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 967

Pregnancy

Manufacturer advises avoid—toxicity in animal studies following systemic administration. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938

PDF page 967

Breast Feeding

Manufacturer advises avoid—no information available.

PDF page 967

Dose and formulations

Directions For Administration

PDF page 967

Medicinal Forms

PDF page 967

Clinical care

Patient And Carer Advice

PDF page 967

Dose text by age group

Adult

Apply once daily, apply thinly to the affected

First-line fragment. Read the complete Indications and Dose section above.

PDF page 967

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.