Drug Action
Chloroprocaine is an ester-type local anaesthetic that blocks the generation and conduction of nerve impulses.
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Drug reference
Chloroprocaine is an ester-type local anaesthetic that blocks the generation and conduction of nerve impulses.
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Spinal anaesthesia for surgical procedures lasting 40 minutes or less (using 10 mg/ml solution) (specialist use only) ▶BY SLOW INTRATHECAL INJECTION ▶Adult: 40–50 mg (max. per dose 50 mg), dose depends on desired length of block Surgical anaesthesia for procedures lasting 60 minutes or less, peripheral nerve block (using 20 mg/ml solution) (specialist use only) ▶BY REGIONAL ADMINISTRATION ▶Adult: (consult product literature)
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Avoid injection into infected tissues . avoid injection into inflamed tissues. hypovolaemia. impaired cardiac conduction. intravenous regional anaesthesia (Bier’s block). severe anaemia CONTRA-INDICATIONS, FURTHER INFORMATION ▶Injection site Local anaesthetics should not be injected into inflamed or infected tissues nor should they be applied to damaged skin. Increased absorption into the blood increases the possibility of systemic side-effects, and the local anaesthetic effect may also be reduced by altered local pH.
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Acute porphyrias p. 1120. cardiovascular disease. complete heart block. debilitated patients (consider dose reduction). elderly (consider dose reduction). low plasma-cholinesterase activity (including severe liver disease). neurological disorders. neuromuscular disorders. partial heart block
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▶Hypersensitivity and cross-sensitivity Hypersensitivity reactions occur mainly with the ester-type local anaesthetics, such as tetracaine and chloroprocaine; reactions are less frequent with the amide types, such as articaine, bupivacaine, levobupivacaine, lidocaine, mepivacaine, prilocaine, and ropivacaine. Cross- sensitivity reactions may be avoided by using the alternative chemical type.
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The licensed doses stated above may not be appropriate in some settings and expert advice should be sought. Should only be administered by, or under the direct supervision of, personnel experienced in their use, with adequate training in anaesthesia and airway management, and should not be administered parenterally unless adequate resuscitation equipment is available.
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→Appendix 1: chloroprocaine
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GENERAL SIDE-EFFECTS ▶Common or very common Anxiety. dizziness. hypotension . nausea. vomiting ▶Uncommon Arrhythmias. hearing impairment. hypertension. loss of consciousness. neurotoxicity. oral disorders. seizure. speech disorder. tinnitus. tremor. vision disorders ▶Rare or very rare Cardiac arrest. drowsiness. faecal incontinence. myocardial contractility decreased. nerve disorders. neurological injury. perineal numbness. sexual dysfunction. urinary incontinence SPECIFIC SIDE-EFFECTS ▶Common or very common ▶With intrathecal use Sensation abnormal ▶When used by regional administration Anaesthetic complication. paraesthesia ▶Uncommon ▶With intrathecal use Headache. pain ▶Rare or very rare ▶With intrathecal use Motor dysfunction. respiratory disorders. spinal block Anaesthesia ▶When used by regional administration Dyspnoea. respiratory arrest
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Manufacturer advises use only if potential benefit outweighs risk (limited information available); this does not preclude use at term for obstetrical anaesthesia.
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Manufacturer advises caution in severe impairment.
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Manufacturer advises use with caution. l HANDLING AND STORAGE Manufacturer advises protect from light.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Chloroprocaine hydrochloride (Non-proprietary) Chloroprocaine hydrochloride 20 mg per 1 ml Ampres 400mg/20ml solution for injection vials | 1 vial P £14.72 ▶Ampres (Sintetica Ltd) Chloroprocaine hydrochloride 10 mg per 1 ml Ampres 50mg/5ml solution for injection ampoules | 10 ampoule P £87.50
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40–50 mg (max. per dose 50 mg), dose depends
First-line fragment. Read the complete Indications and Dose section above.
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(consult product literature)
First-line fragment. Read the complete Indications and Dose section above.
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