Indications And Dose
Schizophrenia and other psychoses | Mania | Short-term adjunctive management of severe anxiety | Psychomotor agitation, excitement, and violent or dangerously impulsive behaviour ▶BY MOUTH ▶Adult: Initially 25 mg 3 times a day, adjusted according to response, alternatively initially 75 mg once daily, adjusted according to response, dose to be taken at night; maintenance 75–300 mg daily, increased if necessary up to 1 g daily, this dose may be required in psychoses; use a third to half adult dose in the elderly or debilitated patients ▶BY RECTUM ▶Adult: 100 mg every 6–8 hours, dose expressed as chlorpromazine base Intractable hiccup ▶BY MOUTH ▶Adult: 25–50 mg 3–4 times a day Relief of acute symptoms of psychoses (under expert supervision) ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: 25–50 mg every 6–8 hours Nausea and vomiting in palliative care (where other drugs have failed or are not available) ▶BY MOUTH ▶Child 1–5 years: 500 micrograms/kg every 4–6 hours; maximum 40 mg per day ▶Child 6–11 years: 500 micrograms/kg every 4–6 hours; maximum 75 mg per day ▶Child 12–17 years: 10–25 mg every 4–6 hours ▶Adult: 10–25 mg every 4–6 hours ▶BY DEEP INTRAMUSCULAR INJECTION ▶Child 1–5 years: 500 micrograms/kg every 6–8 hours; maximum 40 mg per day ▶Child 6–11 years: 500 micrograms/kg every 6–8 hours; maximum 75 mg per day ▶Child 12–17 years: Initially 25 mg, then 25–50 mg every 3–4 hours until vomiting stops ▶Adult: Initially 25 mg, then 25–50 mg every 3–4 hours until vomiting stops ▶BY RECTUM ▶Adult: 100 mg every 6–8 hours DOSE EQUIVALENCE AND CONVERSION ▶For equivalent therapeutic effect 100 mg chlorpromazine base given rectally as a suppository : 20–25 mg chlorpromazine hydrochloride by intramuscular injection: 40–50 mg of chlorpromazine base or hydrochloride given by mouth. l UNLICENSED USE Rectal route is not licensed.
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