Names and pronunciation
(klor-proe′ma-zeen)
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Drug reference
(klor-proe′ma-zeen)
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Func. class.: Antipsychotic/antiemetic
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Do not confuse: chlorproMAZINE/chlorproPAMIDE/ prochlorperazine
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USES: Psychotic disorders, mania, schizophrenia, anxiety, intractable hic- cups in adults, nausea, vomiting; preop- eratively for relaxation; acute intermittent porphyria, behavioral problems in chil- dren, nonpsychotic, demented patients, Tourette’s syndrome
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CONTRAINDICATIONS: Chil- dren <6 mo, hypersensitivity, circulatory collapse, liver damage, cerebral arterio- sclerosis, coronary disease, coma Precautions: Pregnancy, breastfeeding, geriatric patients, seizure disorders, hypertension, hepatic/cardiac disease, prostatic enlargement, Parkinson’s dis- ease, pulmonary disease, severe hypo/ hypertension, blood dyscrasias, brain damage, bone marrow depression, alco- hol/barbiturate withdrawal, closed-angle glaucoma
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Black Box Warning: Dementia; in- creased mortality in geriatric patients with dementia-related psychosis
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DOSAGE AND ROUTES Psychosis • Adult: PO 10-50 mg q1-4hr initially then increase up to 2 g/day if necessary; IM 10- 50 mg q1-4hr, usual dose 300-800 mg/day • Geriatric: PO 10-25 mg daily-bid, in- crease by 10-25 mg/day q4-7days, max 800 mg/day • Child >6 mo: PO/IM 0.56 mg/kg q4- 6hr Nausea and vomiting • Adult: PO 10-25 mg q4-6hr prn; IM 12.5-25 mg q3hr prn, then 25-50 mg q6-8 hr prn if no hypotension, max 400 mg/day; IV 25-50 mg daily-qid • Child ≥6 mo: PO 0.55 mg/kg q4-6hr; IM q6-8hr; IM ≤5 yr or ≤22.7 kg, 40 mg; max IM 5-10 yr or 22.7-45.5 kg, 75 mg Intractable hiccups/acute intermittent porphyria • Adult: PO 25-50 mg tid-qid; IM 25-50 mg (only if PO dose does not work); IV 25-50 mg in 500-1000 mL NS (only for severe hiccups)
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Available forms: Tablets 10, 25, 50, 100, 200 mg; injection 25 mg/mL
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• Child >6 mo: PO/IM 0.56 mg/kg q4- 6hr Nausea and vomiting
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• Child ≥6 mo: PO 0.55 mg/kg q4-6hr; IM q6-8hr; IM ≤5 yr or ≤22.7 kg, 40 mg; max IM 5-10 yr or 22.7-45.5 kg, 75 mg Intractable hiccups/acute intermittent porphyria
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