Therapeutic Action
Sedative antipsychotic
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Drug reference
Sedative antipsychotic
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Acute or chronic psychosis, in the event of intolerance or treatment failure with other antipsychotics (preferably use haloperidol for this indication)
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Do not administer to patients with cardiac disorders (heart failure, recent myocardial infarction, conduction disorders, bradycardia, etc.), dementia (e.g. Alzheimer's disease), closed-angle glaucoma, prostate disorders, Parkinson's disease and history of neuroleptic malignant syndrome. Administer with caution and carefully monitor use in older patients and patients with hypokalaemia, hypotension, renal or hepatic impairment, history of seizures. May cause: drowsiness (caution when driving/operating machinery), dyskinesia, extrapyramidal symptoms, weight gain, orthostatic hypotension, hyperprolactinaemia, anticholinergic effects (dry mouth, blurred vision, urinary retention, constipation, tachycardia); hyperglycaemia, photosensitivity, impaired thermoregulation; agranulocytosis, neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation. In case of extrapyramidal symptoms, try reducing the dose of chlorpromazine or, if the extrapyramidal symptoms are severe, add biperiden or trihexyphenidyl. Avoid or monitor combination with: central nervous system depressants (opioid analgesics, sedatives, H1 antihistamines, etc.); drugs with anticholinergic effects (amitriptyline, atropine, promethazine, etc.), antidiabetics, lithium; antihypertensive drugs (risk of hypotension); drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, fluconazole, mefloquine, pentamidine, quinine, etc.). Avoid alcohol during treatment (increased risk of adverse effects). Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, use the lowest effective dose. Observe the neonate the first few days (risk of agitation, tremors, hypertonia/hypotonia, respiratory difficulties, sleeping disorders, etc.) if the mother was under rd treatment in the 3 trimester. If treatment starts during pregnancy, preferably use haloperidol. Breast-feeding: if absolutely necessary, use the lowest effective dose.
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25 mg and 100 mg tablets
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Adult: 25 to 50 mg once daily in the evening for one week. Increase gradually to 50 mg in the morning and 100 mg in the evening; if insufficient, administer 100 mg 3 times daily. Reduce the dose by half in older patients. Use the lowest effective dose, especially in the event of prolonged treatment.
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Acute psychosis: at least 3 months Chronic psychosis: at least one year Discontinue treatment gradually (over 4 weeks). If signs of relapse occur, increase the dose then decrease it more gradually.
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Do not crush tablets (risk of contact dermatitis).
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– – Below 25 °C
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25 to 50 mg once daily in the evening for one week. Increase gradually to 50 mg in the morning and 100 mg in the evening; if insufficient, administer 100 mg 3 times daily.
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