Drug reference

Chlortalidone

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 266, 267

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Ascites due to cirrhosis in stable patients (under close supervision) | Oedema due to nephrotic syndrome ▶BY MOUTH ▶Adult: Up to 50 mg daily Hypertension ▶BY MOUTH ▶Adult: 25 mg daily, dose to be taken in the morning, then increased if necessary to 50 mg daily Mild to moderate chronic heart failure ▶BY MOUTH ▶Adult: 25–50 mg daily, dose to be taken in the morning, then increased if necessary to 100–200 mg daily, reduce to lowest effective dose for maintenance Nephrogenic diabetes insipidus | Partial pituitary diabetes insipidus ▶BY MOUTH ▶Adult: Initially 100 mg twice daily, then reduced to 50 mg daily

PDF pages 266, 267

Safety

Interactions

→Appendix 1: thiazide diuretics

PDF page 267

Side Effects

▶Common or very common Appetite decreased. gastrointestinal discomfort ▶Uncommon Gout ▶Rare or very rare Arrhythmia. diabetes mellitus exacerbated. eosinophilia. glycosuria. hepatic disorders. nephritis tubulointerstitial. pulmonary oedema. respiratory disorder

PDF page 267

Breast Feeding

The amount present in milk is too small to be harmful. Large doses may suppress lactation.

PDF page 267

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension Tablet ▶Chlortalidone (Non-proprietary) Chlortalidone 25 mg Chlortalidone 25mg tablets | 100 tablet P s Chlortalidone 50 mg Chlortalidone 50mg tablets | 30 tablet P £90.55 DT = £88.04 Combinations available: Triamterene with chlortalidone, p. 244

PDF page 267

Dose text by age group

Adult

Up to 50 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 266

Adult

25 mg daily, dose to be taken in the morning,

First-line fragment. Read the complete Indications and Dose section above.

PDF page 267

Adult

25–50 mg daily, dose to be taken in the

First-line fragment. Read the complete Indications and Dose section above.

PDF page 267

Adult

Initially 100 mg twice daily, then reduced to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 267

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Chlortalidone

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 266, 267

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF pages 266, 267

Safety

Interactions

→Appendix 1: thiazide diuretics

PDF page 267

Side Effects

PDF page 267

Breast Feeding

The amount present in milk is too small to be harmful. Large doses may suppress lactation.

PDF page 267

Dose and formulations

Medicinal Forms

PDF page 267

Dose text by age group

Adult

Up to 50 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 266

Adult

25 mg daily, dose to be taken in the morning,

First-line fragment. Read the complete Indications and Dose section above.

PDF page 267

Adult

25–50 mg daily, dose to be taken in the

First-line fragment. Read the complete Indications and Dose section above.

PDF page 267

Adult

Initially 100 mg twice daily, then reduced to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 267

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.