Indications And Dose
Treatment of testicular, lung, cervical, bladder, head and neck, and ovarian cancer (alone or in combination) ▶BY INTRAVENOUS INFUSION ▶Adult: (consult product literature)
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Drug reference
Treatment of testicular, lung, cervical, bladder, head and neck, and ovarian cancer (alone or in combination) ▶BY INTRAVENOUS INFUSION ▶Adult: (consult product literature)
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Cisplatin requires intensive intravenous hydration and treatment may be complicated by severe nausea and vomiting.
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→Appendix 1: platinum compounds
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▶Common or very common Anaemia. arrhythmias. bone marrow failure. electrolyte imbalance. extravasation necrosis. fever. leucopenia. nephrotoxicity (dose-related and potentially cumulative). sepsis. thrombocytopenia ▶Uncommon Anaphylactoid reaction. ototoxicity (dose- related and potentially cumulative). spermatogenesis abnormal ▶Rare or very rare Acute leukaemia. cardiac arrest. encephalopathy. myocardial infarction. nerve disorders. seizure. stomatitis ▶Frequency not known Alopecia. appetite decreased. asthenia. autonomic dysfunction. cardiac disorder. cerebrovascular insufficiency. deafness. dehydration. diarrhoea. haemolytic anaemia. hiccups. hyperuricaemia. infection. Lhermitte’s sign. malaise. muscle spasms. myelopathy. nausea. papilloedema. pulmonary embolism . rash. Raynaud’s phenomenon. renal impairment. renal tubular disorder. retinal discolouration. SIADH. taste loss . tetany. thrombotic microangiopathy. tinnitus. vision disorders. vomiting
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Manufacturer advises effective contraception during and for at least 6 months after treatment in men or women.
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Avoid (teratogenic and toxic in animal studies. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Discontinue breast-feeding.
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Avoid if possible—nephrotoxic.
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▶Monitor full blood count. ▶Monitor audiology. ▶Monitor plasma electrolytes. ▶Nephrotoxicity Monitoring of renal function is essential.
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Cisplatin is increasingly given in a day care setting.
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There can be variation in the licensing of different medicines containing the same drug. Solution for infusion ▶Cisplatin (Non-proprietary) Cisplatin 1 mg per 1 ml Cisplatin 50mg/50ml concentrate for solution for infusion vials | 1 vial P £24.50–£28.11 DT = £19.50 (Hospital only) Cisplatin 100mg/100ml solution for infusion vials | 1 vial P £50.22 DT = £29.83 (Hospital only) | 1 vial P £8.12 DT = £29.83 Cisplatin 50mg/50ml solution for infusion vials | 1 vial P £4.36– £28.11 DT = £19.50 | 1 vial P £25.37 DT = £19.50 (Hospital only) Cisplatin 10mg/10ml concentrate for solution for infusion vials | 1 vial P £5.36–£5.90 (Hospital only) Cisplatin 100mg/100ml concentrate for solution for infusion vials | 1 vial P £50.22–£55.64 DT = £29.83 (Hospital only)
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(consult product literature)
First-line fragment. Read the complete Indications and Dose section above.
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