Names and pronunciation
(klin-da-mye′sin) Cleocin, Cleocin-T, Clindacin-P, Clindagel, ClindaMax, Clindasol , Clinda-T , Clindesse, Clindets, Dalacin , Evoclin
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Drug reference
(klin-da-mye′sin) Cleocin, Cleocin-T, Clindacin-P, Clindagel, ClindaMax, Clindasol , Clinda-T , Clindesse, Clindets, Dalacin , Evoclin
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Func. class.: Topical antiinfective
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Chem. class.: Lincosamide derivative
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ACTION: Antibacterial activity results from inhibition of protein synthesis; bacteriostatic
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USES: For the treatment of acne vul- garis; treatment of bacterial vaginosis and anaerobic bacteria
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CONTRAINDICATIONS: Hyper- sensitivity to this product or lincomycin, history of antibiotic-associated colitis or ulcerative colitis Precautions: Breastfeeding, children <12 yr
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SIDE EFFECTS GU: Colitis, diarrhea, overgrowth, vagini- tis, vaginal moniliasis, UTI INTEG: Redness, burning, dermatitis, rash, pruritus
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DOSAGE AND ROUTES Acne vulgaris • Adult/adolescent: TOPICAL (gel, lotion, solution) Apply a thin film of 1% to affected areas bid; TOPICAL (foam) Apply 1% topical foam to affected areas once daily; if there is no improvement after 6-8 wk or if the condition worsens, discontinue treatment; TOPICAL (med- icated pledgets) Use a pledget to apply a thin film to the affected area bid Bacterial vaginosis and anaerobic bacteria Nonpregnant adult/adolescent/postme- narchal females: Intravaginal cream: one applicatorful (100 mg clindamycin/5 g cream) intravaginally, preferably at bedtime, for 3 or 7 consecutive days in nonpregnant women and for 7 consecu- tive days in pregnant women; Clindesse is administered as a single dose at any time of the day • Intravaginal ovules/suppositories: 1 ovule (100 mg clindamycin) inserted intravaginally at bedtime for 3 days
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Available forms: Topical gel, foam, lotion, pledget, solution 1%; vaginal cream 2%, vaginal suppositories 100 mg
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Administer: Topical route • Improvement occurs after 6 wk but can require 8-12 wk • Topical skin products are not for in- travaginal therapy and are for external use only; do not use skin products near the eyes, nose, or mouth • Wash hands prior to and after use; wash affected area and gently pat dry Cream/ointment/lotion: Shake well before use (lotion); apply a thin film to the cleansed affected area; massage gen- tly into affected areas Foam formulations: Do not dispense foam directly onto hands or face; the warmth of the skin will cause the foam to melt; apply directly into the cap or onto a cool surface; gently massage into the affected areas Solution formulations: Shake well prior to use; apply a thin film to the cleansed C affected area; massage gently into af- fected areas; if using a solution-soaked pledget, may use more than 1 pledget per application as needed; use only once and then discard Intravaginal route: Only use dosage for- mulations specified for intravaginal use Suppository: Unwrap vaginal ovule (sup- pository) before insertion; use applicator(s) supplied by the manufacturer Cream: Use applicator(s) supplied by the manufacturer
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Assess: • Contact prescriber immediately if se- vere diarrhea, stomach cramps/pain, or bloody stools occur Infection: Assess for number of lesions, severity in acne, itching in vaginosis
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Evaluate: • Decreased lesions in acne, infection in vaginosis
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: Topical route • That improvement occurs after 6 wk but can require 8-12 wk • That topical products are not for in- travaginal therapy and are for external use only; not to use skin products near the eyes, nose, or mouth • To wash hands prior to and after use; to wash affected area and gently pat dry • Cream/ointment/lotion: to shake well prior to use; lotion: to apply a thin film to the cleansed affected area and massage gently into affected area • Foam formulations: not to dispense foam directly onto hands or face; use fingertips and gently massage into the affected areas • Solution formulations: to shake well; to apply a thin film to the cleansed af- fected area and massage gently into af- fected areas; if using a solution-soaked pledget, may use more than one pledget per application as needed; each pledget should be used only once and then dis- carded Intravaginal route • To use only dosage formulations spec- ified for intravaginal use; not to ingest • Suppository: to unwrap vaginal ovule (suppository) before insertion; to use applicator(s) supplied by the manufac- turer • Cream: to use applicator(s) supplied by the manufacturer
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• Adult/adolescent: TOPICAL (gel, lotion, solution) Apply a thin film of 1% to affected areas bid; TOPICAL (foam) Apply 1% topical foam to affected areas once daily; if there is no improvement after 6-8 wk or if the condition worsens, discontinue treatment; TOPICAL (med- icated pledgets) Use a pledget to apply a thin film to the affected area bid Bacterial vaginosis and anaerobic bacteria Nonpregnant adult/adolescent/postme- narchal females: Intravaginal cream: one applicatorful (100 mg clindamycin/5 g cream) intravaginally, preferably at bedtime, for 3 or 7 consecutive days in nonpregnant women and for 7 consecu- tive days in pregnant women; Clindesse is administered as a single dose at any time of the day
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• Intravaginal ovules/suppositories: 1 ovule (100 mg clindamycin) inserted intravaginally at bedtime for 3 days
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