Drug reference

Clobetasol propionate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1332, 1333

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Short-term treatment only of severe resistant inflammatory skin disorders such as recalcitrant eczemas unresponsive to less potent corticosteroids | Psoriasis ▶TO THE SKIN ▶Child 1–17 years: Apply 1–2 times a day for up to 4 weeks, to be applied thinly ▶Adult: Apply 1–2 times a day for up to 4 weeks, to be applied thinly, maximum 50 g of 0.05% preparation per week POTENCY ▶Clobetasol propionate 0.05% cream, foam, ointment, scalp application, and shampoo: very potent. ETRIVEX ® Moderate scalp psoriasis ▶TO THE SKIN ▶Adult: Apply once daily maximum duration of treatment 4 weeks, to be applied thinly then rinsed off after 15 minutes; frequency of application should be reduced after clinical improvement

PDF page 1332

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: cream, ointment, paste Shampoo CAUTIONARY AND ADVISORY LABELS 28 ▶Etrivex (Galderma (UK) Ltd) Clobetasol propionate 500 microgram per 1 gram Etrivex 500micrograms/g shampoo | 125 ml P £9.15 DT = £9.15 Cream CAUTIONARY AND ADVISORY LABELS 28 EXCIPIENTS: May contain Beeswax, cetostearyl alcohol (including cetyl and stearyl alcohol), chlorocresol, propylene glycol ▶ClobaDerm (Accord Healthcare Ltd) Clobetasol propionate 500 microgram per 1 gram ClobaDerm 0.05% cream | 30 gram P £2.56 DT = £2.69 | 100 gram P £7.51 DT = £7.90 ▶Dermovate (GlaxoSmithKline UK Ltd) Clobetasol propionate 500 microgram per 1 gram Dermovate 0.05% cream | 30 gram P £2.69 DT = £2.69 | 100 gram P £7.90 DT = £7.90 Ointment CAUTIONARY AND ADVISORY LABELS 28 EXCIPIENTS: May contain Propylene glycol ▶ClobaDerm (Accord Healthcare Ltd) Clobetasol propionate 500 microgram per 1 gram ClobaDerm 0.05% ointment | 30 gram P £2.56 DT = £2.69 | 100 gram P £7.51 DT = £7.90 ▶Dermovate (GlaxoSmithKline UK Ltd) Clobetasol propionate 500 microgram per 1 gram Dermovate 0.05% ointment | 30 gram P £2.69 DT = £2.69 | 100 gram P £7.90 DT = £7.90 Liquid CAUTIONARY AND ADVISORY LABELS 15, 28 ▶Dermovate (GlaxoSmithKline UK Ltd) Clobetasol propionate 500 microgram per 1 gram Dermovate 0.05% scalp application | 30 ml P £3.07 DT = £3.07 | 100 ml P £10.42 DT = £10.42 Combinations available: Clobetasol propionate with neomycin sulfate and nystatin, p. 1315 eiiii F 1308

PDF pages 1332, 1333

Clinical care

Patient And Carer Advice

Patients or carers should be given advice on how to administer clobetasol propionate foam, liquid (scalp application), cream, ointment and shampoo. Scalp application Patients or carers should be advised to apply foam directly to scalp lesions (foam begins to subside immediately on contact with skin).

PDF page 1332

Dose text by age group

Adult

Apply 1–2 times a day for up to 4 weeks, to be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1332

Adult

Apply once daily maximum duration of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1332

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Clobetasol propionate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1332, 1333

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1332

Dose and formulations

Medicinal Forms

PDF pages 1332, 1333

Clinical care

Patient And Carer Advice

PDF page 1332

Dose text by age group

Adult

Apply 1–2 times a day for up to 4 weeks, to be

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1332

Adult

Apply once daily maximum duration of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1332

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.