Names and pronunciation
(kloe-mip′ra-meen) Anafranil
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Drug reference
(kloe-mip′ra-meen) Anafranil
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Func. class.: Antidepressant, tricyclic
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Chem. class.: Tertiary amine
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Do not confuse: clomiPRAMINE/clomiPHENE
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USES: Obsessive-compulsive disorder
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CONTRAINDICATIONS: Hypersen- sitivity to this product, carBAMazepine, tricy- clics, immediate post-MI, MAOI therapy Precautions: Pregnancy, breastfeeding, geriatric patients, seizures, cardiac dis- ease, glaucoma, prostatic hypertrophy, urinary retention
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Black Box Warning: Children, suicidal ideation
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DOSAGE AND ROUTES Obsessive-compulsive disorder • Adult: PO 25 mg at bedtime, increase gradually over 4 wk to 75-250 mg/day in divided doses • Child 10-18 yr: PO 25 mg/day, gradu- ally increase over 2 wk; max 3 mg/kg/day or 200 mg/day, whichever is smaller
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Available forms: Capsules 25, 50, 75 mg HIGH ALERT
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• Adult: PO 25 mg at bedtime, increase gradually over 4 wk to 75-250 mg/day in divided doses
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• Child 10-18 yr: PO 25 mg/day, gradu- ally increase over 2 wk; max 3 mg/kg/day or 200 mg/day, whichever is smaller
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