Names and pronunciation
(kloe-trim′a-zole) Canesten , Clotrimaderm , Cruex, Desenex Gyne-Lotrimin, Lotrimin, Lotrimin AF, Trivagizole 3
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Drug reference
(kloe-trim′a-zole) Canesten , Clotrimaderm , Cruex, Desenex Gyne-Lotrimin, Lotrimin, Lotrimin AF, Trivagizole 3
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Func. class.: Topical antifungal
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Chem. class.: Imidazole derivative
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Do not confuse: clotrimazole/miconazole/clobetasol
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ACTION: Antifungal activity results from altering cell wall permeability
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USES: Vulvovaginal, oropharyngeal candidiasis; topical fungal infections, prevention of oropharyngeal candidiasis in immunocompromised
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CONTRAINDICATIONS: Hyper- sensitivity, ophthalmic use Precautions: Hepatic impairment (oral)
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SIDE EFFECTS GI: Nausea, vomiting GU: Vaginal burning, irritation INTEG: Burning, peeling, rash, pruritus
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INTERACTIONS Drug/Lab Test Increase: LFTs
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DOSAGE AND ROUTES Tinea corporis, cruris, pedis, versicolor; candidiasis • Adult/child ≥2 yr: TOPICAL apply to affected area and rub into area AM/PM × 2-4 wk Vulvovaginal candidiasis • Adult/child ≥12 yr: VAG CREAM 1 applicator at bedtime × 3 days (2%) or 7 days (1%) Oropharyngeal candidiasis • Adult/child ≥3 yr: LOZENGE 1 PO dissolved 5×/day × 2 wk or adults 1 lozenge dissolved tid (prevention) Oropharyngeal candidiasis prevention in immunocompromised • Adult: PO: Lozenge dissolve tid
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Available forms: Topical cream, solu- tion, 1%; vaginal cream 1%, 2%; lozenges, troches 10 mg
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Administer: Topical route • Topical skin products are not for in- travaginal therapy and are for external use only; do not use skin products near the eyes, nose, or mouth • Wash hands prior to and after use; wash affected area and gently pat dry • Cream/solution: apply to the cleansed affected area; massage gently into affected areas PO route • Troches: allow to dissolve; do not chew or swallow whole Intravaginal route • Only use dosage formulations speci- fied for intravaginal use; intravaginal dos- age forms are not for topical therapy; do not ingest • Cream: use applicator(s) supplied by the manufacturer
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Assess: • Allergic reaction: assess for hyper- sensitivity; product might need to be discontinued • Infection: assess for severity of infec- tion, itching • Hepatic function studies periodically if using oral troches
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Evaluate: • Decreased infection, itching
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: Topical route: • That topical skin products are not for intravaginal therapy and are for external use only; do not use skin products near the eyes, nose, or mouth; do not use oc- clusive dressings • To wash hands prior to and after use; wash affected area and gently pat dry • Cream: to shake well before use; apply a thin film to the cleansed affected area; massage gently into affected areas PO route: • Troches: allow to dissolve; do not chew or swallow whole • Cream: to use applicator(s) supplied by the manufacturer
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PHARMACOKINETICS PO duration 3 hr
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• Adult/child ≥2 yr: TOPICAL apply to affected area and rub into area AM/PM × 2-4 wk Vulvovaginal candidiasis
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• Adult/child ≥12 yr: VAG CREAM 1 applicator at bedtime × 3 days (2%) or 7 days (1%) Oropharyngeal candidiasis
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• Adult/child ≥3 yr: LOZENGE 1 PO dissolved 5×/day × 2 wk or adults 1 lozenge dissolved tid (prevention) Oropharyngeal candidiasis prevention in immunocompromised
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