Therapeutic Action
Penicillin antibacterial
PDF page 383
Loading InternPractice…
Drug reference
Penicillin antibacterial
PDF page 383
Severe infections due to streptococci and/or staphylococci: meningitis, pneumonia, omphalitis, septicaemia of cutaneous origin, endocarditis, osteomyelitis, necrotizing skin and soft tissues infections, etc. Erysipelas, cellulitis
PDF page 383
Do not administer to penicillin-allergic patients. Administer with caution to patients with allergy to cephalosporins (cross-sensitivity may occur) or with renal impairment (reduce the dose). May cause: gastrointestinal disturbances (particularly diarrhoea), allergic reactions sometimes severe; rarely, haematological disorders. Do not combine with methotrexate (increased methotrexate toxicity). Pregnancy and breast-feeding: no contra-indication
PDF page 384
Powder for injection, in 500 mg vial, to be dissolved in 4 ml of water for injection, for IV infusion in 0.9% sodium chloride or 5% glucose, to be administered in 60 minutes
PDF page 383
Severe infections Neonate: 0 to 7 days (< 2 kg): 50 mg/kg every 12 hours 0 to 7 days (≥ 2 kg): 50 mg/kg every 8 hours 8 days to < 1 month (< 2 kg): 50 mg/kg every 8 hours 8 days to < 1 month (≥ 2 kg): 50 mg/kg every 6 hours Child 1 month and over: 25 to 50 mg/kg (max. 2 g) every 6 hours Adult: 2 g every 6 hours 500 mg vial Age Weight (diluted in 4 ml, 125 mg/ml) 1 to < 3 months 4 to < 6 kg 1 ml x 4 3 months to < 1 year 6 to < 10 kg 2 ml x 4 1 to < 5 years 10 to < 20 kg 4 ml x 4 (1 vial x 4) 5 to < 8 years 20 to < 28 kg 8 ml x 4 (2 vials x 4) 8 to < 12 years 28 to < 38 kg 12 ml x 4 (3 vials x 4) ≥ 12 years and adult ≥ 38 kg 16 ml x 4 (4 vials x 4) Dilute each dose of cloxacillin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults. Erysipelas, cellulitis Neonate, child and adult: half of above dose
PDF pages 383, 384
Change to oral route as soon as possible with amoxicillin/clavulanic acid or cefalexin depending on the indication. Do not use oral cloxacillin for completion treatment following parenteral therapy.
PDF page 384
Dicloxacillin, flucloxacillin and oxacillin are used for the same indications. Do not mix with other drugs in the same infusion.
PDF page 384
– Below 25 °C Reconstituted solution must be used immediately.
PDF pages 384, 385
25 to 50 mg/kg (max. 2 g) every 6 hours
PDF page 383
2 g every 6 hours
PDF page 383
half of above dose
PDF page 384