Drug reference
Oedema ▶BY MOUTH ▶Adult: 2.5/20–10/80 mg daily, dose to be taken in the morning DOSE EQUIVALENCE AND CONVERSION ▶A mixture of amiloride hydrochloride and furosemide (frusemide) in the mass proportions of 1 part amiloride hydrochloride to 8 parts furosemide (frusemide).
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Addison’s disease. anuria. comatose or precomatose states associated with liver cirrhosis. dehydration. hyperkalaemia. hypovolaemia. renal failure. severe hypokalaemia. severe hyponatraemia
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Correct hypovolaemia before using in oliguria. diabetes mellitus. elderly. gout. hepatorenal syndrome. hypoproteinaemia. hypotension. impaired micturition. prostatic enlargement
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→Appendix 1: loop diuretics. potassium- sparing diuretics
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Not used to treat hypertension in pregnancy.
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Manufacturers advise avoid—no information regarding amiloride component available. Amount of furosemide in milk too small to be harmful. Furosemide may inhibit lactation.
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Manufacturer advises caution in hepatic cirrhosis with renal impairment.
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Risk of hyperkalaemia in renal impairment but may need higher doses. Avoid if eGFR less than 30 mL/minute/1.73 m2. Monitoring Monitor plasma-potassium concentration. Cardiovascular system
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Monitor electrolytes.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet ▶Co-amilofruse (Non-proprietary) Amiloride hydrochloride 2.5 mg, Furosemide 20 mg Co- amilofruse 2.5mg/20mg tablets | 28 tablet P £12.86 DT = £8.58 | 56 tablet P £17.16–£25.72 Amiloride hydrochloride 5 mg, Furosemide 40 mg Co-amilofruse 5mg/40mg tablets | 28 tablet P £7.94 DT = £5.29 | 56 tablet P £10.58–£15.88 Amiloride hydrochloride 10 mg, Furosemide 80 mg Co-amilofruse 10mg/80mg tablets | 28 tablet P £23.38 DT = £15.52 ▶Frumil (Sanofi) Amiloride hydrochloride 2.5 mg, Furosemide 20 mg Frumil LS 20mg/2.5mg tablets | 28 tablet P £4.32 DT = £8.58 Amiloride hydrochloride 5 mg, Furosemide 40 mg Frumil 40mg/5mg tablets | 28 tablet P £5.29 DT = £5.29 eiiii F 240
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2.5/20–10/80 mg daily, dose to be taken in the
First-line fragment. Read the complete Indications and Dose section above.
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