Drug reference

Co-amilozide

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 199, 200

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Hypertension ▶BY MOUTH ▶Adult: Initially 2.5/25 mg daily, increased if necessary up to 5/50 mg daily Congestive heart failure ▶BY MOUTH ▶Adult: Initially 2.5/25 mg daily; increased if necessary up to 10/100 mg daily, reduce dose for maintenance if possible Oedema and ascites in cirrhosis of the liver ▶BY MOUTH ▶Adult: Initially 5/50 mg daily; increased if necessary up to 10/100 mg daily, reduce dose for maintenance if possible DOSE EQUIVALENCE AND CONVERSION ▶A mixture of amiloride hydrochloride and hydrochlorothiazide in the mass proportions of 1 part amiloride hydrochloride to 10 parts hydrochlorothiazide.

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Contra Indications

Anuria. hyperkalaemia

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Cautions

Diabetes mellitus. elderly

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Safety

Interactions

→Appendix 1: potassium-sparing diuretics . thiazide diuretics

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Side Effects

Angina pectoris. appetite abnormal. arrhythmias. arthralgia. asthenia. chest pain. confusion. constipation. depression. diarrhoea. dizziness. drowsiness. dyspnoea. electrolyte imbalance. erectile dysfunction. ﬂatulence. ﬂushing. gastrointestinal Cardiovascular system discomfort. gastrointestinal haemorrhage. gout. headache. hiccups. hyperhidrosis. insomnia. malaise. muscle cramps. nasal congestion. nausea. nervousness. pain. paraesthesia. postural hypotension. renal impairment. skin reactions. stupor. syncope. taste unpleasant. urinary disorders. vertigo. visual impairment . vomiting

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Breast Feeding

Avoid—no information regarding amiloride component available. Amount of hydrochlorothiazide in milk probably too small to be harmful. Large doses of hydrochlorothiazide may suppress lactation.

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Renal Impairment

Manufacturers advise avoid in severe impairment. Monitoring Monitor plasma-potassium concentration (high risk of hyperkalaemia in renal impairment).

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Monitoring Requirements

Monitor electrolytes.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Tablet ▶Co-amilozide (Non-proprietary) Amiloride hydrochloride 2.5 mg, Hydrochlorothiazide 25 mg Co- amilozide 2.5mg/25mg tablets | 28 tablet P £12.14 DT = £8.64 Amiloride hydrochloride 5 mg, Hydrochlorothiazide 50 mg Co- amilozide 5mg/50mg tablets | 28 tablet P £2.81 DT = £1.87 ▶Moduretic (Merck Sharp & Dohme Ltd) Amiloride hydrochloride 5 mg, Hydrochlorothiazide 50 mg Moduretic 5mg/50mg tablets | 28 tablet P £1.29 DT = £1.87 eiiii F 176

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Dose text by age group

Adult

Initially 2.5/25 mg daily, increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 199

Adult

Initially 2.5/25 mg daily; increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 199

Adult

Initially 5/50 mg daily; increased if necessary up

First-line fragment. Read the complete Indications and Dose section above.

PDF page 199

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Co-amilozide

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 199, 200

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 199

Contra Indications

Anuria. hyperkalaemia

PDF page 199

Cautions

Diabetes mellitus. elderly

PDF page 199

Safety

Interactions

→Appendix 1: potassium-sparing diuretics . thiazide diuretics

PDF page 199

Side Effects

PDF page 200

Breast Feeding

Avoid—no information regarding amiloride component available. Amount of hydrochlorothiazide in milk probably too small to be harmful. Large doses of hydrochlorothiazide may suppress lactation.

PDF page 200

Renal Impairment

Manufacturers advise avoid in severe impairment. Monitoring Monitor plasma-potassium concentration (high risk of hyperkalaemia in renal impairment).

PDF page 200

Monitoring Requirements

Monitor electrolytes.

PDF page 200

Dose and formulations

Medicinal Forms

PDF page 200

Dose text by age group

Adult

Initially 2.5/25 mg daily, increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 199

Adult

Initially 2.5/25 mg daily; increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 199

Adult

Initially 5/50 mg daily; increased if necessary up

First-line fragment. Read the complete Indications and Dose section above.

PDF page 199

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.