Indications And Dose
Infections due to beta-lactamase-producing strains (where amoxicillin alone not appropriate), including respiratory tract infections, bone and joint infections, genito-urinary and abdominal infections, and animal bites ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 250/125 mg every 8 hours; increased to 500/125 mg every 8 hours, increased dose used for severe infection ▶Adult: 250/125 mg every 8 hours; increased to 500/125 mg every 8 hours, increased dose used for severe infection ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g every 8 hours Infections due to beta-lactamase-producing strains (where amoxicillin alone not appropriate) including respiratory-tract infections, bone and joint infections, genito-urinary and abdominal infections, and animal bites (doses for 125/31 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 1–11 months: 0.25 mL/kilogram 3 times a day, dose doubled in severe infection ▶Child 1–5 years: 0.25 mL/kilogram 3 times a day, alternatively 5 mL 3 times a day, dose doubled in severe infection Infections due to beta-lactamase-producing strains (where amoxicillin alone not appropriate) including respiratory-tract infections, bone and joint infections, genito-urinary and abdominal infections, and animal bites (doses for 250/62 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 6–11 years: 0.15 mL/kilogram 3 times a day, alternatively 5 mL 3 times a day, dose doubled in severe infection Infections due to beta-lactamase-producing strains (where amoxicillin alone not appropriate) including respiratory-tract infections, bone and joint infections, genito-urinary and abdominal infections, and animal bites (doses for 400/57 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 2–23 months: 0.15 mL/kilogram twice daily, doubled in severe infection ▶Child 2–6 years (body-weight 13–21 kg): 2.5 mL twice daily, doubled in severe infection ▶Child 7–12 years (body-weight 22–40 kg): 5 mL twice daily, doubled in severe infection ▶Child 12–17 years (body-weight 41 kg and above): 10 mL twice daily; increased if necessary to 10 mL 3 times a day, increased frequency to be used in severe infection ▶Adult: 10 mL twice daily; increased if necessary to 10 mL 3 times a day, increased frequency to be used in severe infection Acute diverticulitis ▶BY MOUTH ▶Adult: 500/125 mg 3 times a day for 5 days then review ▶BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION ▶Adult: 1.2 g every 8 hours Moderate diabetic foot infection | Severe diabetic foot infection ▶BY MOUTH USING TABLETS ▶Adult: 500/125 mg every 8 hours ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g every 8 hours Leg ulcer infection ▶BY MOUTH USING TABLETS ▶Adult: 500/125 mg every 8 hours for 7 days ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g every 8 hours Cellulitis | Erysipelas ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 250/125 mg every 8 hours, alternatively 500/125 mg every 8 hours for 5–7 days then review (review after 7 days in severe infection or if infection near the eyes or nose) ▶Adult: 500/125 mg every 8 hours for 7 days then review ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g every 8 hours Cellulitis (doses for 125/31 suspension) | Erysipelas (doses for 125/31 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 1–11 months: 0.25 mL/kilogram 3 times a day for 5–7 days then review (review after 7 days in severe infection or if infection near the eyes or nose), dose doubled in severe infection ▶Child 1–5 years: 0.25 mL/kilogram 3 times a day, alternatively 5 mL 3 times a day for 5–7 days then review (review after 7 days in severe infection or if infection near the eyes or nose), dose doubled in severe infection Cellulitis (doses for 250/62 suspension) | Erysipelas (doses for 250/62 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 6–11 years: 0.15 mL/kilogram 3 times a day, alternatively 5 mL 3 times a day for 5–7 days then review (review after 7 days in severe infection or if infection near the eyes or nose), dose doubled in severe infection Severe dental infection with spreading cellulitis | Dental infection not responding to first-line antibacterial ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 250/125 mg every 8 hours for 5 days ▶Adult: 250/125 mg every 8 hours for 5 days Surgical prophylaxis Infection ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g, to be administered up to 30 minutes before the procedure, then 1.2 g every 8 hours for up to 2–3 further doses in high risk procedures Community-acquired pneumonia (doses for 125/31 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 1–11 months: 0.5 mL/kilogram 3 times a day for 5 days ▶Child 1–5 years: 0.5 mL/kilogram 3 times a day for 5 days, alternatively 10 mL 3 times a day for 5 days Community-acquired pneumonia (doses for 250/62 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 6–11 years: 0.3 mL/kilogram 3 times a day for 5 days, alternatively 10 mL 3 times a day for 5 days Community-acquired pneumonia ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 500/125 mg 3 times a day for 5 days ▶Adult: 500/125 mg 3 times a day for 5 days ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g every 8 hours Hospital-acquired pneumonia (doses for 125/31 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 1–11 months: 0.5 mL/kilogram 3 times a day for 5 days then review ▶Child 1–5 years: 0.5 mL/kilogram 3 times a day for 5 days then review, alternatively 10 mL 3 times a day for 5 days then review Hospital-acquired pneumonia (doses for 250/62 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 6–11 years: 0.3 mL/kilogram 3 times a day for 5 days then review, alternatively 10 mL 3 times a day for 5 days then review Hospital-acquired pneumonia ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 500/125 mg 3 times a day for 5 days then review ▶Adult: 500/125 mg 3 times a day for 5 days then review Acute exacerbation of bronchiectasis (doses for 125/31 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 1–11 months: 0.25 mL/kilogram 3 times a day for 7–14 days ▶Child 1–5 years: 5 mL 3 times a day for 7–14 days, alternatively 0.25 mL/kilogram 3 times a day for 7–14 days Acute exacerbation of bronchiectasis (doses for 250/62 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 6–11 years: 5 mL 3 times a day for 7–14 days, alternatively 0.15 mL/kilogram 3 times a day for 7–14 days Acute exacerbation of bronchiectasis ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 250/125 mg 3 times a day for 7–14 days, alternatively 500/125 mg 3 times a day for 7–14 days ▶Adult: 500/125 mg 3 times a day for continued → 7–14 days ▶BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION ▶Adult: 1.2 g every 8 hours Acute exacerbation of chronic obstructive pulmonary disease ▶BY MOUTH USING TABLETS ▶Adult: 500/125 mg 3 times a day for 5 days ▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g every 8 hours Infection Acute sinusitis (doses for 125/31 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 1–11 months: 0.25 mL/kilogram 3 times a day for 5 days ▶Child 1–5 years: 5 mL 3 times a day for 5 days, alternatively 0.25 mL/kilogram 3 times a day for 5 days Acute sinusitis (doses for 250/62 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 6–11 years: 5 mL 3 times a day for 5 days, alternatively 0.15 mL/kilogram 3 times a day for 5 days Acute sinusitis ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 250/125 mg 3 times a day for 5 days, alternatively 500/125 mg 3 times a day for 5 days ▶Adult: 500/125 mg 3 times a day for 5 days Acute otitis media (doses for 125/31 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 1–11 months: 0.25 mL/kilogram 3 times a day for 5–7 days ▶Child 1–5 years: 5 mL 3 times a day for 5–7 days, alternatively 0.25 mL/kilogram 3 times a day for 5–7 days Acute otitis media (doses for 250/62 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 6–11 years: 5 mL 3 times a day for 5–7 days, alternatively 0.15 mL/kilogram 3 times a day for 5–7 days Acute otitis media ▶BY MOUTH USING TABLETS ▶Child 12–17 years: 250/125 mg 3 times a day for 5–7 days, alternatively 500/125 mg 3 times a day for 5–7 days Acute pyelonephritis (doses for 125/31 suspension) | Urinary-tract infection (catheter-associated) (doses for 125/31 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 3–11 months: 0.25 mL/kilogram 3 times a day for 7 to 10 days, dose doubled in severe infection ▶Child 1–5 years: 0.25 mL/kilogram 3 times a day, alternatively 5 mL 3 times a day for 7 to 10 days, dose doubled in severe infection Acute pyelonephritis (doses for 250/62 suspension) | Urinary-tract infection (catheter-associated) (doses for 250/62 suspension) ▶BY MOUTH USING ORAL SUSPENSION ▶Child 6–11 years: 0.15 mL/kilogram 3 times a day, alternatively 5 mL 3 times a day for 7 to 10 days, dose doubled in severe infection Acute pyelonephritis | Urinary-tract infection (catheter- associated) ▶BY MOUTH USING TABLETS ▶Child 12–15 years: 250/125 mg 3 times a day for 7–10 days, alternatively 500/125 mg 3 times a day for 7–10 days ▶Child 16–17 years: 500/125 mg 3 times a day for 7–10 days ▶Adult: 500/125 mg 3 times a day for 7–10 days ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g every 8 hours DOSE EQUIVALENCE AND CONVERSION ▶Doses are expressed as co-amoxiclav. ▶A mixture of amoxicillin (as the trihydrate or as the sodium salt) and clavulanic acid (as potassium clavulanate); the proportions are expressed in the form x/y where x and y are the strengths in milligrams of amoxicillin and clavulanic acid respectively. l UNLICENSED USE Co-amoxiclav may be used as detailed below, although these situations are considered unlicensed: . g treatment of acute exacerbation of bronchiectasis . treatment of hospital-acquired pneumonia . duration of treatment for acute sinusitis . duration of treatment for acute otitis media Co-amoxiclav is used for the treatment of acute diverticulitis h, but is not licensed orally for this indication.
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