Drug reference
Mixed infections involving beta-lactamase-producing staphylococci ▶BY MOUTH ▶Child 10–17 years: 250/250 mg every 6 hours ▶Adult: 250/250 mg every 6 hours Severe mixed infections involving beta-lactamase- producing staphylococci ▶BY MOUTH ▶Child 10–17 years: 500/500 mg every 6 hours ▶Adult: 500/500 mg every 6 hours
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Acute lymphocytic leukaemia (increased risk of erythematous rashes). chronic lymphocytic leukaemia (increased risk of erythematous rashes). cytomegalovirus infection (increased risk of erythematous rashes). glandular fever (erythematous rashes common)
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Dose expressed as a combination of equal parts by mass of flucloxacillin and ampicillin.
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HEPATIC DISORDERS Cholestatic jaundice and hepatitis may occur very rarely, up to two months after treatment with flucloxacillin has been stopped. Administration for more than 2 weeks and increasing age are risk factors. Manufacturer advises: . flucloxacillin should not be used in patients with a history of hepatic dysfunction associated with flucloxacillin; . flucloxacillin should be used with caution in patients with hepatic impairment; . careful enquiry should be made about hypersensitivity reactions to beta-lactam antibacterials.
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→Appendix 1: penicillins
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Arthralgia. bronchospasm. coma. dyspnoea. electrolyte imbalance. eosinophilia. erythema nodosum. gastrointestinal disorder. hallucination. Jarisch-Herxheimer reaction. myalgia. purpura non- thrombocytopenic. vasculitis
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Not known to be harmful.
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Trace amount in milk, but appropriate to use.
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Manufacturer advises caution.
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Dose adjustments ▶In adults Reduce dose if eGFR less than 10 mL/minute/1.73 m2; rashes more common. ▶In children Reduce dose or frequency if estimated glomerular filtration rate less than 10 mL/minute/1.73 m2; rashes more common. l EFFECT ON LABORATORY TESTS False-positive urinary glucose (if tested for reducing substances).
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There can be variation in the licensing of different medicines containing the same drug. Capsule CAUTIONARY AND ADVISORY LABELS 9, 22 ▶Co-fluampicil (Non-proprietary) Ampicillin (as Ampicillin trihydrate) 250 mg, Flucloxacillin (as Flucloxacillin sodium) 250 mg Co-fluampicil 250mg/250mg capsules | 28 capsule P £28.71 DT = £2.61 | 100 capsule P £9.32 ANTIBACTERIALS › PENICILLINS, BROAD-SPECTRUM WITH BETA- LACTAMASE INHIBITOR eiiii F 575
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250/250 mg every 6 hours
First-line fragment. Read the complete Indications and Dose section above.
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500/500 mg every 6 hours
First-line fragment. Read the complete Indications and Dose section above.
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