Drug reference

Co-phenotrope

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 93

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Adjunct to rehydration in acute diarrhoea ▶BY MOUTH ▶Child 4–8 years: 1 tablet 3 times a day ▶Child 9–11 years: 1 tablet 4 times a day ▶Child 12–15 years: 2 tablets 3 times a day ▶Child 16–17 years: Initially 4 tablets, followed by 2 tablets every 6 hours until diarrhoea controlled ▶Adult: Initially 4 tablets, followed by 2 tablets every 6 hours until diarrhoea controlled Control of faecal consistency after colostomy or ileostomy ▶BY MOUTH ▶Child 4–8 years: 1 tablet 3 times a day ▶Child 9–11 years: 1 tablet 4 times a day ▶Child 12–15 years: 2 tablets 3 times a day ▶Child 16–17 years: Initially 4 tablets, then 2 tablets 4 times a day ▶Adult: Initially 4 tablets, then 2 tablets 4 times a day

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Contra Indications

Gastro-intestinal obstruction. intestinal atony. myasthenia gravis (but some antimuscarinics may be used to decrease muscarinic side- effects of anticholinesterases). paralytic ileus. prostatic enlargement (in adults). pyloric stenosis. severe ulcerative colitis. signiﬁcant bladder outﬂow obstruction. toxic megacolon. urinary retention

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Cautions

Presence of subclinical doses of atropine may give rise to atropine side-effects in susceptible individuals or in overdosage. young children are particularly susceptible to overdosage; symptoms may be delayed and observation is needed for at least 48 hours after ingestion

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Prescribing And Dispensing Information

A mixture of diphenoxylate hydrochloride and atropine sulfate in the mass proportions 100 parts to 1 part respectively.

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Exceptions To Legal Category

Co-phenotrope 2.5/0.025 can be sold to the public for adults and children over 16 years (provided packs do not contain more than 20 tablets) as an adjunct to rehydration in acute diarrhoea (max. daily dose 10 tablets).

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Safety

Interactions

→Appendix 1: atropine. opioids

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Side Effects

Abdominal discomfort. angioedema. angle closure glaucoma. appetite decreased. cardiac disorder. depression. dysuria. fever. gastrointestinal disorders. malaise. mucosal dryness. mydriasis. restlessness. vision disorders

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Pregnancy

Manufacturer advises caution.

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Breast Feeding

May be present in milk.

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Hepatic Impairment

Manufacturer advises caution; avoid in jaundice.

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Dose and formulations

Directions For Administration

For administration by mouth tablets may be crushed.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: tablet Tablet ▶Co-phenotrope (Non-proprietary) Atropine sulfate 25 microgram, Diphenoxylate hydrochloride 2.5 mg Lomotil 2.5mg/25microgram tablets | 100 tablet P s m eiiii F 467

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Dose text by age group

Child 4–8 years

1 tablet 3 times a day

First-line fragment. Read the complete Indications and Dose section above.

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Child 9–11 years

1 tablet 4 times a day

First-line fragment. Read the complete Indications and Dose section above.

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Child 12–15 years

2 tablets 3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 16–17 years

Initially 4 tablets, followed by

First-line fragment. Read the complete Indications and Dose section above.

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Adult

Initially 4 tablets, followed by 2 tablets every

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 4–8 years

1 tablet 3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 9–11 years

1 tablet 4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 12–15 years

2 tablets 3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 16–17 years

Initially 4 tablets, then 2 tablets

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Adult

Initially 4 tablets, then 2 tablets 4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Co-phenotrope

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 93

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 93

Contra Indications

PDF page 93

Cautions

PDF page 93

Prescribing And Dispensing Information

A mixture of diphenoxylate hydrochloride and atropine sulfate in the mass proportions 100 parts to 1 part respectively.

PDF page 93

Exceptions To Legal Category

PDF page 93

Safety

Interactions

→Appendix 1: atropine. opioids

PDF page 93

Side Effects

PDF page 93

Pregnancy

Manufacturer advises caution.

PDF page 93

Breast Feeding

May be present in milk.

PDF page 93

Hepatic Impairment

Manufacturer advises caution; avoid in jaundice.

PDF page 93

Dose and formulations

Directions For Administration

For administration by mouth tablets may be crushed.

PDF page 93

Medicinal Forms

PDF page 93

Dose text by age group

Child 4–8 years

1 tablet 3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 9–11 years

1 tablet 4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 12–15 years

2 tablets 3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 16–17 years

Initially 4 tablets, followed by

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Adult

Initially 4 tablets, followed by 2 tablets every

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 4–8 years

1 tablet 3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 9–11 years

1 tablet 4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 12–15 years

2 tablets 3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Child 16–17 years

Initially 4 tablets, then 2 tablets

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Adult

Initially 4 tablets, then 2 tablets 4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 93

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.