Drug reference
Hypertension ▶BY MOUTH ▶Adult: 50/12.5 mg daily, alternatively increased if necessary to 100/25 mg daily, doses higher than 50 mg atenolol rarely necessary DOSE EQUIVALENCE AND CONVERSION ▶A mixture of atenolol and chlortalidone in mass proportions corresponding to 4 parts of atenolol and 1 part chlortalidone.
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→Appendix 1: beta blockers, selective. thiazide diuretics
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▶Common or very common Gastrointestinal disorder. glucose tolerance impaired ▶Rare or very rare Alopecia. hepatic disorders. mood altered. neutropenia. psychosis ▶Frequency not known Lupus-like syndrome
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Avoid. Diuretics not used to treat hypertension in pregnancy.
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Atenolol present in milk in greater Cardiovascular system amounts than some other beta-blockers. Possible toxicity due to beta-blockade—monitor infant. Large doses of chlortalidone may suppress lactation.
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Avoid if eGFR less than 30 mL/minute/1.73 m2—consider alternative treatment.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 8 ▶Co-tenidone (Non-proprietary) Chlortalidone 12.5 mg, Atenolol 50 mg Co-tenidone 50mg/12.5mg tablets | 28 tablet P £4.85 DT = £1.61 Chlortalidone 25 mg, Atenolol 100 mg Co-tenidone 100mg/25mg tablets | 28 tablet P £4.85 DT = £1.82 ▶Tenoret (AstraZeneca UK Ltd) Chlortalidone 12.5 mg, Atenolol 50 mg Tenoret 50mg/12.5mg tablets | 28 tablet P £10.36 DT = £1.61 ▶Tenoretic (AstraZeneca UK Ltd) Chlortalidone 25 mg, Atenolol 100 mg Tenoretic 100mg/25mg tablets | 28 tablet P £10.36 DT = £1.82 eiiii F 159
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50/12.5 mg daily, alternatively increased if
First-line fragment. Read the complete Indications and Dose section above.
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