Indications And Dose
Hyperlipidaemias, particularly type IIa, in patients who have not responded adequately to diet and other appropriate measures | Primary prevention of coronary heart disease in men aged 35–59 years with primary hypercholesterolaemia who have not responded to diet and other appropriate measures ▶BY MOUTH ▶Adult: Initially 4 g daily, increased in steps of 4 g every week; increased to 12–24 g daily in 1–4 divided doses, adjusted according to response; maximum 36 g per day Pruritus associated with partial biliary obstruction and primary biliary cirrhosis ▶BY MOUTH ▶Adult: 4–8 g once daily Diarrhoea associated with Crohn’s disease, ileal resection, vagotomy, diabetic vagal neuropathy, and radiation ▶BY MOUTH ▶Adult: Initially 4 g daily, increased in steps of 4 g every week; increased to 12–24 g daily in 1–4 divided doses, adjusted according to response, if no response within 3 days an alternative therapy should be initiated; maximum 36 g per day Accelerated elimination of teriflunomide ▶BY MOUTH ▶Adult: 8 g 3 times a day for 11 days; reduced to 4 g 3 times a day, dose should only be reduced if not tolerated Accelerated elimination of leflunomide (washout procedure) ▶BY MOUTH ▶Adult: 8 g 3 times a day for 11 days
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