Drug reference
Acute attacks of hereditary angioedema in patients with C1-esterase inhibitor deficiency ▶BY SLOW INTRAVENOUS INJECTION ▶Adult (body-weight up to 84 kg): 50 units/kg for 1 dose, to be administered over 5 minutes, dose may be repeated if necessary; maximum 2 doses per day ▶Adult (body-weight 84 kg and above): 4200 units for 1 dose, to be administered over 5 minutes, dose may be repeated if necessary; maximum 2 doses per day
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Rabbit allergy
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Scottish Medicines Consortium (SMC) decisions SMC No. 745/11 The Scottish Medicines Consortium has advised (August 2018) that conestat alfa (Ruconest ®) is accepted for use within NHS Scotland for the treatment of acute angioedema attacks in adults and adolescents with hereditary angioedema due to C1 esterase inhibitor deficiency. This advice is contingent upon the continuing availability of the patient access scheme in NHS Scotland or a list price that is equivalent or lower. All Wales Medicines Strategy Group (AWMSG) decisions AWMSG No. 786 The All Wales Medicines Strategy Group has advised (November 2018) that conestat alfa (Ruconest ®) is recommended as an option for use within NHS Wales for the treatment of acute angioedema attacks in adults and adolescents with hereditary angioedema due to C1 esterase inhibitor deficiency. This recommendation applies only in circumstances where the approved Wales Patient Access Scheme (WPAS) is utilised or where the list/contract price is equivalent or lower than the WPAS price.
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▶Common or very common Headache ▶Uncommon Abdominal discomfort. diarrhoea. nausea. oral paraesthesia. paraesthesia. throat irritation. urticaria . vertigo
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Use only if potential benefit outweighs risk— toxicity in animal studies.
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Use only if potential benefit outweighs risk—no information available.
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There can be variation in the licensing of different medicines containing the same drug. Powder for solution for injection ▶Ruconest (Pharming Group N.V.) Conestat alfa 2100 unit Ruconest 2,100unit powder for solution for injection vials | 1 vial P £750.00 DRUGS USED IN HEREDITARY ANGIOEDEMA › KALLIKREIN INHIBITORS
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50 units/kg for 1 dose,
First-line fragment. Read the complete Indications and Dose section above.
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4200 units for
First-line fragment. Read the complete Indications and Dose section above.
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