Names and pronunciation
(kris′a-bor-ole) Eucrisa
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Drug reference
(kris′a-bor-ole) Eucrisa
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Func. class.: Dermatologic agent
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Chem. class.: Phosphodiesterase 4 enzyme inhibitor
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ACTION: Increases intracellular cyclic adenosine monophosphate (cAMP) levels in the skin
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USES: Mild to moderate atopic C dermatitis
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CONTRAINDICATIONS: Hyper sensitivity Precautions: Children, pregnancy, breastfeeding
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SIDE EFFECTS INTEG: Burning, stinging, application site pain
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INTERACTIONS • None known
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DOSAGE AND ROUTES • Adult/child ≥2 yr: TOPICAL; Apply ointment bid in a thin film to cover area
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Available forms: Topical ointment 2%
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Administer: Topical route: • For external use only; store at room temperature • Tube should be tightly closed • Apply only to affected areas
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Assess: • Contact dermatitis: for redness, itch- ing, inflammation; assess if these symp- toms are relieved after application • Hypersensitivity: for pruritus, inflam- mation, rash; if present, product should be discontinued • Pregnancy/breastfeeding: no adverse reactions in animal studies, no human studies available; consider benefits to mother and infant if breastfeeding; prod- uct is systemically absorbed
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Evaluate: • Therapeutic response: decreasing redness, itching, inflammation
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: • Contact dermatitis: to identify whether symptoms are relieved after application; to apply a thin film and wash hands after use; to use externally only • Hypersensitivity: to report immedi- ately itching, inflammation, rash; if pres- ent, product should be discontinued • Pregnancy/breastfeeding: to advise prescriber if pregnant or planning to get pregnant, or if breastfeeding; effects are unknown
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PHARMACOKINETICS 97% protein bound, excreted renally
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• Adult/child ≥2 yr: TOPICAL; Apply ointment bid in a thin film to cover area
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