Drug reference

Crisantaspase

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1006

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Crisantaspase is the enzyme asparaginase produced by Erwinia chrysanthemi.

PDF page 1006

Indications And Dose

Acute lymphoblastic leukaemia ▶BY INTRAMUSCULAR INJECTION, OR BY SUBCUTANEOUS INJECTION, OR BY INTRAVENOUS INJECTION ▶Adult: (consult product literature)

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Contra Indications

History of pancreatitis related to asparaginase therapy

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Cautions

Diabetes (may raise blood glucose)

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Safety

Interactions

→Appendix 1: crisantaspase

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Side Effects

▶Common or very common Chills. coagulation disorders. confusion. diarrhoea. dizziness. drowsiness. dyspnoea. face oedema. fever. headache. hepatic disorders. hypersensitivity. limb swelling. lip swelling. neurotoxicity. pain. pallor. pancreatitis. seizures. skin reactions. thrombosis ▶Uncommon Hyperglycaemia. hyperlipidaemia. hypoxia. increased risk of infection. respiratory disorders ▶Rare or very rare Arthritis reactive. coma. diabetic ketoacidosis. dysphagia. dysphasia. encephalopathy. haemorrhage. level of consciousness decreased. myalgia. myocardial infarction. necrotising pancreatitis. neutropenia. paresis. sepsis. thrombocytopenia ▶Frequency not known Abdominal pain. ﬂushing. hyperammonaemia. hypertension. hypotension. nausea. pseudocyst. vomiting

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Conception And Contraception

Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.

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Pregnancy

Avoid. See also, Pregnancy and reproductive function in Cytotoxic drugs p. 938.

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Breast Feeding

Discontinue breast-feeding.

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Dose and formulations

Directions For Administration

Facilities for the management of anaphylaxis should be available.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder for solution for injection ▶Erwinase (Jazz Pharmaceuticals UK) Crisantaspase 10000 unit Erwinase 10,000unit powder for solution for injection vials | 5 vial P £3,065.00

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Dose text by age group

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1006

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Crisantaspase

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1006

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Crisantaspase is the enzyme asparaginase produced by Erwinia chrysanthemi.

PDF page 1006

Indications And Dose

Acute lymphoblastic leukaemia ▶BY INTRAMUSCULAR INJECTION, OR BY SUBCUTANEOUS INJECTION, OR BY INTRAVENOUS INJECTION ▶Adult: (consult product literature)

PDF page 1006

Contra Indications

History of pancreatitis related to asparaginase therapy

PDF page 1006

Cautions

Diabetes (may raise blood glucose)

PDF page 1006

Safety

Interactions

→Appendix 1: crisantaspase

PDF page 1006

Side Effects

PDF page 1006

Conception And Contraception

Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 1006

Pregnancy

Avoid. See also, Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 1006

Breast Feeding

Discontinue breast-feeding.

PDF page 1006

Dose and formulations

Directions For Administration

Facilities for the management of anaphylaxis should be available.

PDF page 1006

Medicinal Forms

PDF page 1006

Dose text by age group

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1006

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.