Drug reference
Tuberculosis resistant to first-line drugs, in combination with other drugs ▶BY MOUTH ▶Adult: Initially 250 mg every 12 hours for 2 weeks, then increased if necessary up to 500 mg every 12 hours, dose to be increased according to blood concentration and response
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▶Cycloserine penetrates the CNS.
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Alcohol dependence. depression. epilepsy. psychotic states. severe anxiety
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→Appendix 1: cycloserine
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Behaviour abnormal. coma. confusion. congestive heart failure. drowsiness. dysarthria. Infection headache. hyperirritability. megaloblastic anaemia. memory loss. neurological effects. paraesthesia. paresis. psychosis. rash. reflexes increased. seizures. suicidal ideation. tremor. vertigo SIDE-EFFECTS, FURTHER INFORMATION CNS toxicity Discontinue or reduce dose if symptoms of CNS toxicity occur. Rashes or allergic dermatitis Discontinue or reduce dose if rashes or allergic dermatitis develop.
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Manufacturer advises use only if potential benefit outweighs risk—crosses the placenta.
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Present in milk—amount too small to be harmful.
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Dose adjustments Increase interval between doses if creatinine clearance less than 50 mL/minute. Monitoring Monitor blood-cycloserine concentration if creatinine clearance less than 50 mL/minute.
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▶Blood concentration monitoring required especially in renal impairment or if dose exceeds 500 mg daily or if signs of toxicity; blood concentration should not exceed 30 mg/litre. ▶Monitor haematological, renal, and hepatic function.
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There can be variation in the licensing of different medicines containing the same drug. Capsule CAUTIONARY AND ADVISORY LABELS 2, 8 ▶Cycloserine (Non-proprietary) Cycloserine 250 mg Cycloserine 250mg capsules | 100 capsule P £442.89 DT = £442.89
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Initially 250 mg every 12 hours for 2 weeks, then
First-line fragment. Read the complete Indications and Dose section above.
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