Indications And Dose
Symptomatic relief of allergy such as hay fever, urticaria | Pruritus ▶BY MOUTH ▶Adult: 4 mg 3 times a day, usual dose 4–20 mg daily; maximum 32 mg per day
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Drug reference
Symptomatic relief of allergy such as hay fever, urticaria | Pruritus ▶BY MOUTH ▶Adult: 4 mg 3 times a day, usual dose 4–20 mg daily; maximum 32 mg per day
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Avoid in Acute porphyrias p. 1120
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Epilepsy. prostatic hypertrophy. pyloroduodenal obstruction. susceptibility to angle- closure glaucoma. urinary retention
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→Appendix 1: antihistamines, sedating
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Aggression. agranulocytosis. anxiety. appetite abnormal. arrhythmias. bronchial secretion viscosity increased. chest tightness. chills. confusion. constipation. coordination abnormal. diarrhoea. dizziness. drowsiness. dry mouth. dry throat. epigastric distress. epistaxis. fatigue. haemolytic anaemia. hallucination. headache. hepatic disorders. hyperhidrosis . hypotension. insomnia. labyrinthitis. leucopenia. menstruation irregular. mood altered. nasal complaints. nausea. neuritis. oedema. palpitations. paraesthesia. photosensitivity reaction. seizure. skin reactions. thrombocytopenia. tinnitus. tremor. urinary disorders. vertigo. vision disorders. vomiting. weight increased. wheezing
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Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity. Use in the latter part of the third trimester may cause adverse effects in neonates such as irritability, paradoxical excitability, and tremor. Respiratory system
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Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 2 ▶Periactin (Teva UK Ltd) Cyproheptadine hydrochloride 4 mg Periactin 4mg tablets | 30 tablet p £5.99 DT = £5.99
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Driving and skilled tasks Drowsiness may affect performance of skilled tasks (e.g. driving); sedating effects enhanced by alcohol.
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4 mg 3 times a day, usual dose 4–20 mg daily;
First-line fragment. Read the complete Indications and Dose section above.
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