Drug reference
Prophylaxis of cytomegalovirus infection in patients taking immunosuppressants, particularly transplant recipients (specialist use only) ▶BY INTRAVENOUS INFUSION ▶Adult: (consult product literature)
PDF page 1379
Selective IgA deficiency with IgA antibodies
PDF page 1379
Interference with live virus vaccines CAUTIONS, FURTHER INFORMATION ▶Interference with live virus vaccines Cytomegalovirus immunoglobulin may impair the immune response to live virus vaccines; such vaccines should only be given 3 months after CMV immunoglobulin treatment. Patients receiving measles vaccines should have their antibody status checked as impairment of immune response may persist for up to 1 year.
PDF page 1379
→Appendix 1: immunoglobulins
PDF page 1379
Arthralgia. back pain. chills. cutaneous lupus erythematosus. dizziness. embolism and thrombosis. fatigue. fever. haemolysis. haemolytic anaemia. headache. hypotension. infusion related reaction. meningitis aseptic. myocardial infarction. nausea. neutropenia. renal impairment. skin reactions. stroke. transfusion-related acute lung injury. vomiting
PDF page 1379
▶Manufacturer advises monitor for signs of infusion-related reactions during and for at least one hour after each infusion in patients receiving cytomegalovirus immunoglobulin for the first time, or following a prolonged period between treatments, or when a different human immunoglobulin has been used previously; monitor all other patients for at least 20 minutes after each infusion—in case of reaction, reduce rate or stop infusion as clinically appropriate. ▶Manufacturer advises monitor urine output and serum creatinine. l HANDLING AND STORAGE Care must be taken to store all immunological products under the conditions recommended in the product literature, otherwise the preparation may become ineffective. Refrigerated storage is usually necessary; many immunoglobulins need to be stored at 2–8°C and not allowed to freeze. Immunoglobulins should be protected from light. Opened multidose vials must be used within the period recommended in the product literature.
PDF page 1379
There can be variation in the licensing of different medicines containing the same drug. Solution for infusion ▶Cytomegalovirus immunoglobulin (Non-proprietary) Cytomegalovirus immunoglobulin human 100 unit per 1 ml Cytotect CP Biotest 5,000units/50ml solution for infusion vials | 1 vial P £917.70 Cytotect CP Biotest 1,000units/10ml solution for infusion vials | 1 vial P £183.54
PDF page 1379
(consult product literature)
First-line fragment. Read the complete Indications and Dose section above.
PDF page 1379
