Names and pronunciation
(dap′a-gli-floe′zin/sax-a-glip′tin) Qtern
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Drug reference
(dap′a-gli-floe′zin/sax-a-glip′tin) Qtern
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Func. class.: Oral antidiabetic
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Chem. class.: Sodium-glucose cotransporter 2 (SGLT-2) inhibitor/di- peptidyl peptidase-4 (DPP-4) inhibitor antidiabetics
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USES: Type 2 diabetes mellitus, with diet and exercise
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CONTRAINDICATIONS: Dialy- sis, renal failure, hypersensitivity, breast- feeding, diabetic ketoacidosis Precautions: Pregnancy, children, renal/hepatic disease, hypothyroidism, hyperglycemia, hypotension, bladder cancer, hypercholesterolemia, pituitary D insufficiency, type 1 diabetes mellitus, malnutrition, fever, dehydration, adrenal insufficiency, geriatrics, genital fungal infections, hypoglycemia
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DOSAGE AND ROUTES Type 2 diabetes mellitus • Adult: PO 10 mg dapagliflozin and 5 mg saxagliptin once daily, taken in the morning, with or without food Renal dose • Adult: PO eGFR 45 mL/min/1.73 m2 or more: no change; eGFR <45 mL/min/1.73 m2: do not start in these patients. In pa- tients currently taking the product, discon- tinue when eGFR is persistently <60 mL/ min/1.73 m2; eGFR <45 mL/min/1.73 m2: do not use
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Available forms: Tablets 10 mg, 5 mg
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• Adult: PO 10 mg dapagliflozin and 5 mg saxagliptin once daily, taken in the morning, with or without food Renal dose
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• Adult: PO eGFR 45 mL/min/1.73 m2 or more: no change; eGFR <45 mL/min/1.73 m2: do not start in these patients. In pa- tients currently taking the product, discon- tinue when eGFR is persistently <60 mL/ min/1.73 m2; eGFR <45 mL/min/1.73 m2: do not use
PDF page 347