Therapeutic Action
Antiretroviral, HIV protease inhibitor
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Drug reference
Antiretroviral, HIV protease inhibitor
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HIV infection, in combination with ritonavir (booster) and other antiretrovirals
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Do not administer to children under 3 years; and to patients with severe hepatic impairment or allergy to sulfonamides (risk of cross-sensitivity). Do not combine with rifampicin (decreased plasma concentrations of darunavir). Replace rifampicin with rifabutin. Administer with caution and monitor use in patients with haemophilia (increased bleeding) or mild to moderate hepatic impairment. May cause: gastrointestinal disturbances, headache, insomnia, fatigue, dizziness, peripheral neuropathy, renal disorders, myocardial infarction, hypertension, tachycardia, hyperglycaemia, hyperlipidaemia, lipodystrophy; skin rash sometimes severe, hepatic disorders; in this event, stop treatment immediately. Darunavir in combination with ritonavir reduces the efficacy of implants and oral contraceptives: use injectable medroxyprogesterone or an intrauterine device. Pregnancy: no contra-indication; use 2 times daily dosing due to decreased plasma concentrations of darunavir during pregnancy.
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75 mg, 150 mg, 400 mg and 600 mg tablets 400 mg darunavir/50 mg ritonavir tablet
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Patients with no previous use of protease inhibitors Single formulations Child 14 to < 35 kg: 600 mg once daily (+ 100 mg ritonavir once daily) Child ≥ 35 kg and adult: 800 mg once daily (+ 100 mg ritonavir once daily) Fixed-dose combination Child ≥ 40 kg and ≥ 12 years and adult: two 400/50 mg tablets once daily Patients with previous use of protease inhibitors Single formulations Child 14 to < 25 kg: 375 mg 2 times daily (+ 50 mg ritonavir 2 times daily) Child 25 to < 35 kg: 400 mg 2 times daily (+ 100 mg ritonavir 2 times daily) Child ≥ 35 kg and adult: 600 mg 2 times daily (+ 100 mg ritonavir 2 times daily)
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Depending on the efficacy and tolerance of darunavir and ritonavir.
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Take with meals together with ritonavir.
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– Below 25 °C
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800 mg once daily (+ 100 mg ritonavir once daily)
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two 400/50 mg tablets once daily
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600 mg 2 times daily (+ 100 mg ritonavir 2 times daily)
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