Names and pronunciation
(da-si′ti-nib) Sprycel
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Drug reference
(da-si′ti-nib) Sprycel
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Func. class.: Antineoplastic—miscel- laneous
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Chem. class.: Protein-tyrosine kinase inhibitor
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USES: Treatment of accelerated, chronic blast phase CML or acute lym- phoblastic leukemia (ALL); chronic phase CML with resistance or intolerance to prior therapy; Philadelphia chro- mosome–positive CML in chronic phase
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CONTRAINDICATIONS: Preg- nancy, hypersensitivity
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DOSAGE AND ROUTES Accelerated or myeloid/lymphoid blast phase CML with resistance/ intolerance to prior therapy • Adult: PO 140 mg daily titrated up to 180 mg daily in those resistant to therapy Chronic phase CML with resistance/ intolerance to prior therapy • Adult: PO 100 mg daily either AM or PM Dosage reduction for those taking a strong CYP3A4 inhibitor • Adult: PO 20-40 mg daily
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Available forms: Tablets 20, 50, 70, 80, 100, 140 mg HIGH ALERT
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• Adult: PO 140 mg daily titrated up to 180 mg daily in those resistant to therapy Chronic phase CML with resistance/ intolerance to prior therapy
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• Adult: PO 100 mg daily either AM or PM Dosage reduction for those taking a strong CYP3A4 inhibitor
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• Adult: PO 20-40 mg daily
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