Names and pronunciation
(daw-noe-roo′bi-sin) Cerubidine
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Drug reference
(daw-noe-roo′bi-sin) Cerubidine
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Func. class.: Antineoplastic, antibiotic
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Chem. class.: Anthracycline glycoside
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USES: Acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML)
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CONTRAINDICATIONS: Preg- nancy, breastfeeding, hypersensitivity, systemic infections, cardiac disease, bone marrow depression
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Black Box Warning: IM/SUBCUT use Precautions: Tumor lysis syndrome, MI, infection, thrombocytopenia, renal/ hepatic disease; gout Black Box Warning: Bone marrow sup- pression, cardiac disease, extravasation, renal failure, hepatic disease; requires a specialized care setting and an experi- enced clinician
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DOSAGE AND ROUTES • Adult <60 yr: IV 45 mg/m2/day × 3 days, first cycle, then 2 days second cycle • Adult >−60 yr: IV 30 mg/m2/day × 3 days, then 2 days of subsequent courses in combination, max 400-600 mg/m2 to- tal cumulative dose • Child ≥2 yr: IV 25 mg/m2/day depend- ing on cycle weekly in combination; <2 yr or BSA <0.5 determine on mg/m2/kg basis
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Available forms: Injection 5 mg/mL HIGH ALERT
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• Child ≥2 yr: IV 25 mg/m2/day depend- ing on cycle weekly in combination; <2 yr or BSA <0.5 determine on mg/m2/kg basis
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