Drug reference

Decitabine

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 982

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Decitabine is a pyrimidine analogue.

PDF page 982

Indications And Dose

Treatment of newly diagnosed acute myeloid leukaemia in patients over 65 years of age who are not candidates for standard induction chemotherapy ▶BY INTRAVENOUS INFUSION ▶Elderly: (consult local protocol)

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Cautions

History of severe congestive heart failure. history of unstable cardiac disease

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Safety

Interactions

→Appendix 1: decitabine

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Side Effects

▶Common or very common Anaemia. diarrhoea. epistaxis. fever. headache. hypersensitivity. increased risk of infection. leucopenia. nausea. neutropenia. sepsis. stomatitis. thrombocytopenia. vomiting ▶Uncommon Acute febrile neutrophilic dermatosis. pancytopenia ▶Frequency not known Gastrointestinal disorders. interstitial lung disease

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Conception And Contraception

Men must avoid fathering a child during and for 3 months after treatment.

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Pregnancy

Avoid (teratogenic in animal studies). See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.

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Breast Feeding

Discontinue breast-feeding.

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Hepatic Impairment

Manufacturer advises caution—no information available.

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Renal Impairment

Manufacturer advises caution if creatinine clearance less than 30 mL/minute—no information available.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion ELECTROLYTES: May contain Potassium, sodium ▶Dacogen (Janssen-Cilag Ltd) Decitabine 50 mg Dacogen 50mg powder for concentrate for solution for infusion vials | 1 vial P £970.86

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Dose text by age group

Elderly

(consult local protocol)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 982

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Decitabine

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 982

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Decitabine is a pyrimidine analogue.

PDF page 982

Indications And Dose

PDF page 982

Cautions

History of severe congestive heart failure. history of unstable cardiac disease

PDF page 982

Safety

Interactions

→Appendix 1: decitabine

PDF page 982

Side Effects

PDF page 982

Conception And Contraception

Men must avoid fathering a child during and for 3 months after treatment.

PDF page 982

Pregnancy

Avoid (teratogenic in animal studies). See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 982

Breast Feeding

Discontinue breast-feeding.

PDF page 982

Hepatic Impairment

Manufacturer advises caution—no information available.

PDF page 982

Renal Impairment

Manufacturer advises caution if creatinine clearance less than 30 mL/minute—no information available.

PDF page 982

Dose and formulations

Medicinal Forms

PDF page 982

Dose text by age group

Elderly

(consult local protocol)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 982

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.