Names and pronunciation
(def-a′sir-ox) Exjade, Jadence , Jadenu, Jadenu Sprinkle
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Drug reference
(def-a′sir-ox) Exjade, Jadence , Jadenu, Jadenu Sprinkle
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Func. class.: Heavy-metal chelating agent
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USES: Chronic iron overload, transfu- sion hemosiderosis
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CONTRAINDICATIONS: Breast- feeding, children, hypersensitivity, severe renal/hepatic disease, GI hemorrhage
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Black Box Warning: Renal failure, GI bleeding/perforation, hepatotoxicity, nephrotoxicity
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DOSAGE AND ROUTES • Adult and child >2 yr: PO (Jadenu) Esti- mated GFR >60 mL/min/1.73 m2: Initial, 14 mg/kg orally once daily; adjust in increments of 3.5 or 7 mg/kg every 3-6 mo based on clinical response and goals; use lowest effec- tive dose to provide a trend in decreasing ferritin; if not adequately controlled with 21 mg/kg/day (e.g., serum ferritin levels persis- tently >2500 mcg/L and not decreasing over time), may increase to a max of 28 mg/kg/ day; consider dose reduction if serum ferritin falls below 1000 mcg/L at 2 consecutive visits (especially if dose is >17.5 mg/kg/day); if serum ferritin falls below 500 mcg/L, inter- rupt therapy and monitor monthly (Exjade) Estimated GFR >60 mL/min/1.73 m2: Initial, 20 mg/kg orally once daily; ad- just in increments of 5 or 10 mg/kg every 3-6 mo based on clinical response and goals; use lowest effective dose to provide a trend in decreasing ferritin; max 40 mg/kg
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Available forms: Tablets 90, 180, 360 mg; oral suspension tablets 125, 250, 500 mg; sprinkles 90, 180, 360 mg HIGH ALERT
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• Adult and child >2 yr: PO (Jadenu) Esti- mated GFR >60 mL/min/1.73 m2: Initial, 14 mg/kg orally once daily; adjust in increments of 3.5 or 7 mg/kg every 3-6 mo based on clinical response and goals; use lowest effec- tive dose to provide a trend in decreasing ferritin; if not adequately controlled with 21 mg/kg/day (e.g., serum ferritin levels persis- tently >2500 mcg/L and not decreasing over time), may increase to a max of 28 mg/kg/ day; consider dose reduction if serum ferritin falls below 1000 mcg/L at 2 consecutive visits (especially if dose is >17.5 mg/kg/day); if serum ferritin falls below 500 mcg/L, inter- rupt therapy and monitor monthly (Exjade) Estimated GFR >60 mL/min/1.73 m2: Initial, 20 mg/kg orally once daily; ad- just in increments of 5 or 10 mg/kg every 3-6 mo based on clinical response and goals; use lowest effective dose to provide a trend in decreasing ferritin; max 40 mg/kg
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