Drug reference
Susceptible infections (e.g. chlamydia, rickettsia and mycoplasma) ▶BY MOUTH ▶Adult: 150 mg 4 times a day, alternatively 300 mg twice daily Treatment of hyponatraemia resulting from inappropriate secretion of antidiuretic hormone, if fluid restriction alone does not restore sodium concentration or is not tolerable ▶BY MOUTH ▶Adult: Initially 0.9–1.2 g daily in divided doses, maintenance 600–900 mg daily
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Photosensitivity more common than with other tetracyclines
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→Appendix 1: tetracyclines
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▶Rare or very rare Agranulocytosis. aplastic anaemia. hearing impairment. nephritis. severe cutaneous adverse reactions (SCARs) ▶Frequency not known Intracranial pressure increased. muscle weakness. nephrogenic diabetes insipidus. vision disorders
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Dose adjustments Manufacturer advises maximum 1 g daily in divided doses.
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May exacerbate renal failure and should not be given to patients with renal impairment.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: tablet, oral suspension, oral solution Tablet ▶Demeclocycline hydrochloride (Non-proprietary) Infection Demeclocycline hydrochloride 150 mg Demeclocycline 150mg tablets | 100 tablet P s Capsule CAUTIONARY AND ADVISORY LABELS 7, 9, 11, 23 ▶Demeclocycline hydrochloride (Non-proprietary) Demeclocycline hydrochloride 150 mg Demeclocycline 150mg capsules | 28 capsule P £200.66 DT = £200.66 ▶Ledermycin (Imported (Netherlands)) Demeclocycline hydrochloride 300 mg Ledermycin 300mg capsules | 16 capsule P s eiiii F above
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Patients should be advised to avoid exposure to sunlight or sun lamps.
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150 mg 4 times a day, alternatively 300 mg twice
First-line fragment. Read the complete Indications and Dose section above.
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Initially 0.9–1.2 g daily in divided doses,
First-line fragment. Read the complete Indications and Dose section above.
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