Names and pronunciation
(dess-ox′ee-met′ah-sone) Topicort, Topicort Spray
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Drug reference
(dess-ox′ee-met′ah-sone) Topicort, Topicort Spray
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Func. class.: Corticosteroid, topical
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ACTION: Crosses cell membrane to attach to receptors to decrease inflam- mation, itching; inhibits multiple inflam- matory cytokines
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USES: Inflammation/itching of corti- costeroid-responsive dermatoses on the skin; spray—plaque psoriasis
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CONTRAINDICATIONS: Hyper- sensitivity, use of some preparations on face, axilla, groin, intertriginous areas; monotherapy in primary bacterial infec- tion, TB Precautions: Pregnancy, breastfeeding, children, skin infections, Cushing’s syndrome
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SIDE EFFECTS INTEG: Burning, folliculitis, pruritus, dermatitis, maceration MISC: Hyperglycemia, glycosuria, sys- temic absorption, hypothalamic- pituitary-adrenal (HPA) axis suppres- sion, Cushing’s syndrome
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DOSAGE AND ROUTES Dermatosis (except spray) • Adult/child >10 yr: Apply to affected areas 2 times/day Plaque psoriasis (spray) Adult: Spray, apply to affected areas, rub gently bid for ≤4 wk
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Available forms: Cream 0.05%, 0.25%; ointment 0.05%, 0.25%; gel 0.05%; spray 0.25%
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Administer: Topical route • Do not use with occlusive dressings • Cream/ointment/lotion: apply spar- ingly in a thin film and rub gently into the cleansed affected area • Gel: apply sparingly in a thin film and rub gently into the cleansed affected area • Spray: discard after 30 days; keep away from heat/flame; store at room temperature
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Assess: • Skin reactions: burning, pruritus, fol- liculitis, dermatitis • Systemic absorption: HPA suppres- sion and possible adrenocortical insuffi- ciency after stopping treatment • Pregnancy/breastfeeding: if preg- nancy is planned or suspected; no well- controlled studies; use only if benefit outweighs fetal risk; caution use in breastfeeding; do not apply to breast
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Evaluate: • Decrease in itching, inflammation on the skin
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: Topical route • Not to use with occlusive dressings • Cream/ointment/lotion: apply spar- ingly in a thin film and rub gently into the cleansed affected area • Gel: apply sparingly in a thin film and rub gently into the cleansed affected area • Spray: discard after 30 days; keep away from heat/flame; store at room temperature
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• Adult/child >10 yr: Apply to affected areas 2 times/day Plaque psoriasis (spray) Adult: Spray, apply to affected areas, rub gently bid for ≤4 wk
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