Indications And Dose
Maintenance of sedation during intensive care ▶BY INTRAVENOUS INFUSION ▶Adult: 0.7 microgram/kg/hour, adjusted according to response; usual dose 0.2–1.4 micrograms/kg/hour
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Drug reference
Maintenance of sedation during intensive care ▶BY INTRAVENOUS INFUSION ▶Adult: 0.7 microgram/kg/hour, adjusted according to response; usual dose 0.2–1.4 micrograms/kg/hour
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Acute cerebrovascular disorders. second- or third-degree AV block (unless pacemaker fitted). uncontrolled hypotension
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Abrupt withdrawal after prolonged use. bradycardia. elderly (risk of hypotension). ischaemic heart disease (especially at higher doses). malignant hyperthermia. severe cerebrovascular disease (especially at higher doses). severe neurological disorders. spinal cord injury
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Dexmedetomidine should only be administered by, or under the direct supervision of, personnel experienced in its use, with adequate training in anaesthesia and airway management.
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→Appendix 1: dexmedetomidine
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▶Common or very common Agitation. arrhythmias. dry mouth. hyperglycaemia. hypertension. hyperthermia. hypoglycaemia. hypotension. myocardial infarction. myocardial ischaemia. nausea. respiratory depression. vomiting ▶Uncommon Abdominal distension. apnoea. atrioventricular block. dyspnoea. hallucination. hypoalbuminaemia. metabolic acidosis. thirst
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Manufacturer advises avoid unless potential benefit outweighs risk—toxicity in animal studies.
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Manufacturer advises avoid unless potential benefit outweighs risk—present in milk in animal studies.
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Manufacturer advises caution (increased risk of toxicity due to decreased clearance). Dose adjustments Manufacturer advises consider dose reduction.
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▶Monitor cardiac function. ▶Monitor respiratory function in non-intubated patients.
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To be diluted before use. For intravenous infusion given continuously in Glucose 5% or Sodium chloride 0.9%, dilute to a concentration of 4 micrograms/mL.
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There can be variation in the licensing of different medicines containing the same drug. Solution for infusion ▶Dexmedetomidine (Non-proprietary) Dexmedetomidine (as Dexmedetomidine hydrochloride) 100 microgram per 1 ml Dexmedetomidine 1mg/10ml concentrate for solution for infusion vials | 4 vial P £313.10 (Hospital only) Dexmedetomidine 400micrograms/4ml concentrate for solution for infusion vials | 4 vial P £125.30 (Hospital only) Dexmedetomidine 200micrograms/2ml concentrate for solution for infusion ampoules | 5 ampoule P £78.30 (Hospital only) ▶Dexdor (Orion Pharma (UK) Ltd) Dexmedetomidine (as Dexmedetomidine hydrochloride) 100 microgram per 1 ml Dexdor 1mg/10ml concentrate for solution for infusion vials | 4 vial P £313.20 (Hospital only) Dexdor 400micrograms/4ml concentrate for solution for infusion vials | 4 vial P £125.28 (Hospital only) Dexdor 200micrograms/2ml concentrate for solution for infusion ampoules | 5 ampoule P £78.30 (Hospital only) | 25 ampoule P £391.50 (Hospital only) Malignant hyperthermia MUSCLE RELAXANTS › DIRECTLY ACTING
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0.7 microgram/kg/hour, adjusted according to
First-line fragment. Read the complete Indications and Dose section above.
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