Therapeutic Action
Anxiolytic, sedative, antiseizure (anticonvulsant), muscle relaxant
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Drug reference
Anxiolytic, sedative, antiseizure (anticonvulsant), muscle relaxant
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Severe anxiety, insomnia, and agitation
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Do not administer to patients with severe respiratory insufficiency, severe hepatic impairment or acute alcohol intoxication. Administer with caution: to older patients and patients with renal or hepatic impairment (reduce the dose by half); to patients with history of drug/substance abuse or mental health disorders. May cause: hypotension, muscle weakness, ataxia, hypotonia, drowsiness (caution when driving/operating machinery), lethargy, confusion, impaired concentration, memory loss, hyperactive or aggressive behaviour; withdrawal syndrome or rebound effect if prolonged treatment is discontinued abruptly; respiratory depression and coma in the event of overdose. Avoid or monitor in combination with: drugs containing alcohol, opioid analgesics, antipsychotics, first-generation antihistamines (hydroxyzine, promethazine), antidepressants, other antiseizure medications, etc. (increased sedation); enzyme inducers such as rifampicin, rifabutin, nevirapine, phenobarbital, phenytoin, carbamazepine, etc. (reduced effect of diazepam); omeprazole, macrolides, ritonavir, isoniazid, fluconazole, itraconazole, etc. (increased diazepam toxicity); phenytoin (increased phenytoin toxicity). Avoid alcohol during treatment (increased risk of adverse effects). Pregnancy and breast-feeding: avoid (passage through the placenta and breast milk)
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2 mg and 5 mg tablets
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Anxiety Adult: 2.5 to 5 mg 2 times daily for 2 to 3 weeks max. reducing the dose by half the last days before stopping treatment Insomnia Adult: 2 to 5 mg once daily at bedtime for 7 days max. Agitation Adult: 10 mg single dose
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Diazepam is subject to international controls: follow national regulations. Diazepam is also used in the treatment of pre-delirium tremens (alcohol withdrawal) in adults: 10 mg every 6 hours for 1 to 3 days, then reduce and stop over 7 days.
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– – Below 25 °C
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2.5 to 5 mg 2 times daily for 2 to 3 weeks max. reducing the dose by half the last days before stopping treatment
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2 to 5 mg once daily at bedtime for 7 days max.
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10 mg single dose
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