Drug reference

Diclofenac sodium with misoprostol

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1222, 1223

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

ARTHROTEC ® 50/200 Prophylaxis against NSAID-induced gastroduodenal ulceration in patients requiring diclofenac for rheumatoid arthritis or osteoarthritis ▶BY MOUTH ▶Adult: 1 tablet 2–3 times a day, take with food ARTHROTEC ® 75/200 Prophylaxis against NSAID-induced gastroduodenal ulceration in patients requiring diclofenac for rheumatoid arthritis or osteoarthritis ▶BY MOUTH ▶Adult: 1 tablet twice daily, take with food MISOFEN ® 50/200 Prophylaxis against NSAID-induced gastroduodenal ulceration in patients requiring diclofenac for rheumatoid arthritis or osteoarthritis ▶BY MOUTH ▶Adult: 1 tablet 2–3 times a day, take with food MISOFEN ® 75/200 Prophylaxis against NSAID-induced gastroduodenal ulceration in patients requiring diclofenac for rheumatoid arthritis or osteoarthritis ▶BY MOUTH ▶Adult: 1 tablet twice daily, take with food l UNLICENSED USE The BNF recommends a higher starting dose of misoprostol for prophylaxis against NSAID- induced gastroduodenal ulceration than that provided by the combination preparations of diclofenac and misoprostol.

PDF pages 1222, 1223

Safety

Interactions

→Appendix 1: NSAIDs

PDF page 1223

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Gastro-resistant tablet CAUTIONARY AND ADVISORY LABELS 21, 25 ▶Arthrotec (Pfizer Ltd) Misoprostol 200 microgram, Diclofenac sodium 50 mg Arthrotec 50 gastro-resistant tablets | 60 tablet P £11.98 DT = £11.98 Misoprostol 200 microgram, Diclofenac sodium 75 mg Arthrotec 75 gastro-resistant tablets | 60 tablet P £15.83 DT = £15.83 ▶Misofen (Morningside Healthcare Ltd) Misoprostol 200 microgram, Diclofenac sodium 50 mg Misofen 50mg/200microgram gastro-resistant tablets | 60 tablet P £11.98 DT = £11.98 Misoprostol 200 microgram, Diclofenac sodium 75 mg Misofen 75mg/200microgram gastro-resistant tablets | 60 tablet P £15.83 DT = £15.83

PDF page 1223

Dose text by age group

Adult

1 tablet 2–3 times a day, take with food

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1222

Adult

1 tablet twice daily, take with food

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1222

Adult

1 tablet 2–3 times a day, take with food

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1222

Adult

1 tablet twice daily, take with food

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1222

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Diclofenac sodium with misoprostol

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1222, 1223

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF pages 1222, 1223

Safety

Interactions

→Appendix 1: NSAIDs

PDF page 1223

Dose and formulations

Medicinal Forms

PDF page 1223

Dose text by age group

Adult

1 tablet 2–3 times a day, take with food

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1222

Adult

1 tablet twice daily, take with food

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1222

Adult

1 tablet 2–3 times a day, take with food

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1222

Adult

1 tablet twice daily, take with food

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1222

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.