Names and pronunciation
(dye-fen-ox′in/a′troe-peen) Motofen
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Drug reference
(dye-fen-ox′in/a′troe-peen) Motofen
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Func. class.: Antidiarrheal
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Chem. class.: Phenylpiperidine derivative opiate agonist Controlled Substance Schedule V diphenoxylate/atropine Controlled Substance Schedule IV difenoxin/atropine
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USES: Acute nonspecific and acute exac- erbations of chronic functional diarrhea
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CONTRAINDICATIONS: Children <2 yr, hypersensitivity, CDAD, severe elec- trolyte imbalances, diarrhea associated with organisms that penetrate intestinal mucosa
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DOSAGE AND ROUTES Diphenoxylate/atropine • Adult: PO 5 mg qid titrated to patient response needed, max 8 tablets/day • Child 2-12 yr: PO (liquid only) 0.3-0.4 mg/kg/day in 4 divided doses Difenoxin/atropine D • Adult: PO 2 tablets, then 1 tablet after each loose stool or q3-4hr prn, max 8 tablets/day
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Available forms: Diphenoxylate/atropine 2.5 mg/0.025 mg/5 mL solution, tablet; difenoxin/atropine tablet 1 mg/0.025 mg
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• Adult: PO 5 mg qid titrated to patient response needed, max 8 tablets/day
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• Child 2-12 yr: PO (liquid only) 0.3-0.4 mg/kg/day in 4 divided doses Difenoxin/atropine D
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• Adult: PO 2 tablets, then 1 tablet after each loose stool or q3-4hr prn, max 8 tablets/day
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