Names and pronunciation
(di-jox′in im-myoon′ FAB) DigiFab
PDF page 395
Loading InternPractice…
Drug reference
(di-jox′in im-myoon′ FAB) DigiFab
PDF page 395
Func. class.: Antidote—digoxin specific
PDF page 395
USES: Life-threatening digoxin toxicity
PDF page 395
CONTRAINDICATIONS: Mild digoxin toxicity, hypersensitivity to this product, papain or ovine protein
PDF page 395
DOSAGE AND ROUTES 1 (40 mg) DigiFab binds 0.5 mg digoxin Digoxin toxicity (known amount) (tablets, oral solution, IM) • Adult and child: IV dose (mg) = dose ingested (mg) × 0.8/1000 × 38- or 40-mg vial Toxicity (known amount) (capsule, IV) • Adult and child: IV dose = dose in- D gested (mg)/0.5 × 38- or 40-mg vial Toxicity (known amount) by serum digoxin concentrations (SDCs) • Adult and child: IV SDC (ng/mL) × kg of weight/100 × 38- or 40-mg vial Digoxin toxicity (unknown amount) • Adult and child >20 kg: IV 228 mg (6 vials) • Infant and child <20 kg: IV 38 mg (1 vial) Acute ingestion • Adult: IV 380 mg (10 vials) Life-threatening ingestion • Adult: IV 760 mg (20 vials) Skin test • Adult: ID 0.1 mL of 1:100 dilution, check after 20 min HIGH ALERT
PDF page 395
• Adult and child: IV dose (mg) = dose ingested (mg) × 0.8/1000 × 38- or 40-mg vial Toxicity (known amount) (capsule, IV)
PDF page 395
• Adult and child: IV dose = dose in- D gested (mg)/0.5 × 38- or 40-mg vial Toxicity (known amount) by serum digoxin concentrations (SDCs)
PDF page 395
• Adult and child: IV SDC (ng/mL) × kg of weight/100 × 38- or 40-mg vial Digoxin toxicity (unknown amount)
PDF page 395
• Adult and child >20 kg: IV 228 mg (6 vials)
PDF page 395
• Infant and child <20 kg: IV 38 mg (1 vial) Acute ingestion
PDF page 395
• Adult: IV 380 mg (10 vials) Life-threatening ingestion
PDF page 395
• Adult: IV 760 mg (20 vials) Skin test
PDF page 395
• Adult: ID 0.1 mL of 1:100 dilution, check after 20 min HIGH ALERT
PDF page 395