Therapeutic Action
Antimalarial
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Drug reference
Antimalarial
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Treatment of uncomplicated falciparum malaria Treatment of uncomplicated malaria due to other Plasmodium species, when chloroquine cannot be used Completion treatment following parenteral therapy for severe malaria
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Do not administer in the event of cardiac disorders (bradycardia, heart rhythm disorders, congestive heart failure). Do not combine with drugs that prolong the QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc. Administer with caution to patients > 60 years or with renal or hepatic impairment. May cause: cardiac disorders (QT prolongation, tachycardia); rarely, gastrointestinal disturbances, pruritus, hepatic disorders, joint and muscle pain. Monitor combination with: antiretrovirals (increased blood levels of these drugs), enzymes inducers such as rifampicin, carbamazepine, phenytoin, phenobarbital (reduced blood levels of DHA/PPQ). If the patient vomits within 30 minutes after administration, re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose. Pregnancy: no contra-indication Breast-feeding: no contra-indication
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Co-formulated tablets of dihydroartemisinin (DHA)/piperaquine (PPQ), in blister pack, for a complete treatment for one individual There are 5 different blister packs: 20 mg DHA/160 mg PPQ tablets blister pack of 3 tablets 40 mg DHA/320 mg PPQ tablets blister pack of 3 tablets 40 mg DHA/320 mg PPQ tablets blister pack of 6 tablets 40 mg DHA/320 mg PPQ tablets blister pack of 9 tablets 40 mg DHA/320 mg PPQ tablets blister pack of 12 tablets
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Child 5 to < 25 kg: 2.5 to 10 mg/kg daily of DHA + 20 to 32 mg/kg daily of PPQ Child 25 kg and over and adult: 2 to 10 mg/kg daily of DHA + 16 to 27 mg/kg daily of PPQ Weight 20 mg/160 mg tablet 40 mg/320 mg tablet 5 to < 8 kg 1 tab – 8 to < 11 kg 1½ tab – 11 to < 17 kg – 1 tab 17 to < 25 kg – 1½ tab 25 to < 36 kg – 2 tab 36 to < 60 kg – 3 tab 60 to < 80 kg – 4 tab ≥ 80 kg – 5 tab Tablets are to be taken once daily for 3 days.
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Take 3 hours before or after meals, with a glass of water. The tablets may be crushed and mixed with water.
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- - Below 25 °C
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2.5 to 10 mg/kg daily of DHA + 20 to 32 mg/kg daily of PPQ
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2 to 10 mg/kg daily of DHA + 16 to 27 mg/kg daily of PPQ
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