Names and pronunciation
Colace, Diocto, DOK, Enemeez, Selax , Silace
PDF page 408
Loading InternPractice…
Drug reference
Colace, Diocto, DOK, Enemeez, Selax , Silace
PDF page 408
Func. class.: Laxative, emollient; stool softener
PDF page 408
Chem. class.: Anionic surfactant
PDF page 408
Do not confuse: Colace/Cozaar Dulcolax (docusate)/Dulcolax (bisacodyl)
PDF page 408
ACTION: Increases water, fat penetra- tion in intestine; allows for easier pas- sage of stool
PDF page 408
USES: Prevention of dry, hard stools
PDF page 408
CONTRAINDICATIONS: Hyper- sensitivity, obstruction, fecal impaction, nausea/vomiting Precautions: Pregnancy, breastfeeding
PDF page 408
SIDE EFFECTS EENT: Bitter taste, throat irritation GI: Nausea, anorexia, cramps, diarrhea INTEG: Rash
PDF page 408
INTERACTIONS • Toxicity: mineral oil Drug/Herb Increase: laxative action—flax, senna
PDF page 408
DOSAGE AND ROUTES • Adult: PO 50-400 mg/day in divided doses (sodium) or 240 mg daily (cal- cium); Rectal ENEMA 4 mL • Child >12 yr: ENEMA 2 mL • Child 6-12 yr: PO 40-150 mg/day (sodium) in divided doses • Child 3-6 yr: PO 20-60 mg/day (sodium) in divided doses • Child <3 yr: PO 10-40 mg/day (sodium) in divided doses • Infant: PO 5 mg/kg/day in divided doses
PDF page 408
Available forms: Calcium: 240 mg; sodium: capsules 50, 100, 250 mg; tab- lets 100 mg; syrup 20 mg/5 mL; liquid 50 mg/5 mL, enema 283 mg/5 mL
PDF page 408
Administer: • Swallow tablets whole; do not break, crush, or chew • Oral solution: diluted in milk, fruit juice to decrease bitter taste • In morning or evening (oral dose) • Store in cool environment; do not freeze
PDF page 408
Assess: • Cause constipation; identify of whether fluids, bulk, or exercise is miss- ing from lifestyle; constipating products • Cramping, rectal bleeding, nausea, vomiting; if these occur, product should be discontinued • Pregnancy/breastfeeding: low risk of fetal harm in pregnancy, breastfeeding
PDF page 408
Evaluate: • Therapeutic response: decrease in constipation
PDF page 408
CLINICAL CONSIDERATIONS
PDF page 408
Patient and caregiver information: • That normal bowel movements do not always occur daily • Not to use in presence of abdominal pain, nausea, vomiting • To notify prescriber if constipation is unrelieved or if symptoms of electrolyte imbalance occur: muscle cramps, pain, weakness, dizziness, excessive thirst • That product may take up to 3 days to soften stools • To take oral preparations with a full glass of water (unless on fluid restric- tions) and to increase fluid intake HIGH ALERT
PDF page 408
PHARMACOKINETICS Onset 12-72 hr (PO), 2-15 min (rectal)
PDF page 408
• Infant: PO 5 mg/kg/day in divided doses
PDF page 408