Drug Action
Dopamine is a cardiac stimulant which acts on beta1 receptors in cardiac muscle, and increases contractility with little effect on rate.
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Drug reference
Dopamine is a cardiac stimulant which acts on beta1 receptors in cardiac muscle, and increases contractility with little effect on rate.
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Cardiogenic shock in infarction or cardiac surgery ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 2–5 micrograms/kg/minute
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Phaeochromocytoma. tachyarrhythmia
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Correct hypovolaemia. hypertension (may raise blood pressure). hyperthyroidism. low dose in shock due to acute myocardial infarction
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→Appendix 1: sympathomimetics, inotropic
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Angina pectoris. anxiety. arrhythmias. azotaemia. cardiac conduction disorder. dyspnoea. gangrene. headache. hypertension. mydriasis. nausea. palpitations. piloerection. polyuria. tremor. vasoconstriction. vomiting
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No evidence of harm in animal studies— manufacturer advises use only if potential benefit outweighs risk.
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May suppress lactation—not known to be harmful.
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Dopamine concentrate for intravenous infusion to be diluted before use. For intravenous infusion give continuously in Glucose 5% or Sodium chloride 0.9%. Dilute to max. concentration of 3.2 mg/mL; incompatible with bicarbonate.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: solution for infusion Solution for infusion ▶Dopamine hydrochloride (Non-proprietary) Dopamine hydrochloride 40 mg per 1 ml Dopamine 200mg/5ml solution for infusion ampoules | 5 ampoule P £20.00 (Hospital only) | 5 ampoule P £20.00 | 10 ampoule P £9.04 Dopamine 200mg/5ml concentrate for solution for infusion ampoules | 10 ampoule P s Dopamine hydrochloride 160 mg per 1 ml Dopamine 800mg/5ml solution for infusion ampoules | 10 ampoule P s SYMPATHOMIMETICS › VASOCONSTRICTOR
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Initially 2–5 micrograms/kg/minute
First-line fragment. Read the complete Indications and Dose section above.
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